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Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates
Chemistry Department, Faculty of Science at Qena, South Valley University, P.O. Box 83523, Qena, Egypt
Department of Chemistry, Faculty of Science, University of Kuwait, P.O. Box 5969, Safat 13060, Kuwait
* Authors to whom correspondence should be addressed.
Received: 27 January 2012; in revised form: 13 May 2012 / Accepted: 15 May 2012 / Published: 18 May 2012
Abstract: The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives.
Keywords: 3-oxo-3-phenyl-2-phenylhydrazonal; arylazonicotinic acid; pyridine; electrocyclization; heteroaromatics
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MDPI and ACS Style
Zaky, O.S.; Moustafa, M.S.; Selim, M.A.; El-Maghraby, A.M.; Elnagdi, M.H. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules 2012, 17, 5924-5934.
Zaky OS, Moustafa MS, Selim MA, El-Maghraby AM, Elnagdi MH. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules. 2012; 17(5):5924-5934.
Zaky, Omniya Sayed; Moustafa, Moustafa Sherief; Selim, Maghraby Ali; El-Maghraby, Awatef Mohamed; Elnagdi, Mohamed Hilmy. 2012. "Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates." Molecules 17, no. 5: 5924-5934.