Molecules 2012, 17(5), 5924-5934; doi:10.3390/molecules17055924
Article

Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates

Omniya Sayed Zaky 1,* email, Moustafa Sherief Moustafa 2,* email, Maghraby Ali Selim 1 , Awatef Mohamed El-Maghraby 1  and Mohamed Hilmy Elnagdi 2
1 Chemistry Department, Faculty of Science at Qena, South Valley University, P.O. Box 83523, Qena, Egypt 2 Department of Chemistry, Faculty of Science, University of Kuwait, P.O. Box 5969, Safat 13060, Kuwait
* Authors to whom correspondence should be addressed.
Received: 27 January 2012; in revised form: 13 May 2012 / Accepted: 15 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Heterocycles)
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Abstract: The reaction of 3-oxo-3-phenyl-2-phenylhydrazonal with functionally substituted and heteroaromatic substituted acetonitrile to yield arylazonicotinic acid derivatives and 5-arylsubstituted pyridines was established. In some cases the produced nicotinates could not be isolated as they underwent thermally induced 6π-electrocyclization yielding polynuclear pyridine derivatives.
Keywords: 3-oxo-3-phenyl-2-phenylhydrazonal; arylazonicotinic acid; pyridine; electrocyclization; heteroaromatics

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Cite This Article

MDPI and ACS Style

Zaky, O.S.; Moustafa, M.S.; Selim, M.A.; El-Maghraby, A.M.; Elnagdi, M.H. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules 2012, 17, 5924-5934.

AMA Style

Zaky OS, Moustafa MS, Selim MA, El-Maghraby AM, Elnagdi MH. Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates. Molecules. 2012; 17(5):5924-5934.

Chicago/Turabian Style

Zaky, Omniya Sayed; Moustafa, Moustafa Sherief; Selim, Maghraby Ali; El-Maghraby, Awatef Mohamed; Elnagdi, Mohamed Hilmy. 2012. "Scope and Limitations of a Novel Synthesis of 3-Arylazonicotinates." Molecules 17, no. 5: 5924-5934.

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