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Molecules 2012, 17(5), 4962-4971; doi:10.3390/molecules17054962
Article

Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives

1,*  and 2,*
Received: 20 February 2012; in revised form: 23 March 2012 / Accepted: 18 April 2012 / Published: 30 April 2012
(This article belongs to the Special Issue Heterocycles)
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Abstract: Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2-ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the other hand, refluxing of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide in ethanol containing a few drops of acetic acid gave pyrazoline-1-thiocarboxamides and isonicotinoyl pyrazolines, respectively. The structures of the synthesized compounds were determined on the basis of their elemental analyses and spectroscopic data. The antimicrobial activity of the newly isolated heterocyclic compounds was evaluated against Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed a moderate degree of potent antimicrobial activity.
Keywords: isonicotinic acid hydrazide; sulphonamide; pyrazoles; antimicrobial activities isonicotinic acid hydrazide; sulphonamide; pyrazoles; antimicrobial activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sharshira, E.M.; Hamada, N.M.M. Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives. Molecules 2012, 17, 4962-4971.

AMA Style

Sharshira EM, Hamada NMM. Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives. Molecules. 2012; 17(5):4962-4971.

Chicago/Turabian Style

Sharshira, Essam Mohamed; Hamada, Nagwa Mohamed Mahrous. 2012. "Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives." Molecules 17, no. 5: 4962-4971.



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