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Molecules 2012, 17(5), 5915-5923; doi:10.3390/molecules17055915

Tropical Plant Extracts as Potential Antihyperglycemic Agents

1,* , 2 and 1
1 Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia 2 School of Medicine and Health Sciences, Monash University, Sunway Campus, Bandar Sunway, Selangor 46150, Malaysia
* Author to whom correspondence should be addressed.
Received: 7 April 2012 / Revised: 28 April 2012 / Accepted: 30 April 2012 / Published: 18 May 2012
(This article belongs to the Section Metabolites)
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Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, a-amylase and a-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.
Keywords: type 2 diabetes mellitus; a-glucosidase; a-amylase; antioxidant; total phenolic content type 2 diabetes mellitus; a-glucosidase; a-amylase; antioxidant; total phenolic content
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Manaharan, T.; Palanisamy, U.D.; Ming, C.H. Tropical Plant Extracts as Potential Antihyperglycemic Agents. Molecules 2012, 17, 5915-5923.

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