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Modifications on the Basic Skeletons of Vinblastine and Vincristine
Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary
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Received: 30 March 2012; in revised form: 9 May 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
Abstract: The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
Keywords: antitumor therapy; vinblastine; vincristine; derivatives
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Keglevich, P.; Hazai, L.; Kalaus, G.; Szántay, C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules 2012, 17, 5893-5914.
Keglevich P, Hazai L, Kalaus G, Szántay C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules. 2012; 17(5):5893-5914.
Keglevich, Péter; Hazai, László; Kalaus, György; Szántay, Csaba. 2012. "Modifications on the Basic Skeletons of Vinblastine and Vincristine." Molecules 17, no. 5: 5893-5914.