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Molecules 2012, 17(5), 5893-5914; doi:10.3390/molecules17055893

Modifications on the Basic Skeletons of Vinblastine and Vincristine

Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary
Author to whom correspondence should be addressed.
Received: 30 March 2012 / Revised: 9 May 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)
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The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
Keywords: antitumor therapy; vinblastine; vincristine; derivatives antitumor therapy; vinblastine; vincristine; derivatives
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Keglevich, P.; Hazai, L.; Kalaus, G.; Szántay, C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules 2012, 17, 5893-5914.

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