Molecules 2012, 17(5), 5893-5914; doi:10.3390/molecules17055893

Modifications on the Basic Skeletons of Vinblastine and Vincristine

Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary
* Author to whom correspondence should be addressed.
Received: 30 March 2012; in revised form: 9 May 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)
PDF Full-text Download PDF Full-Text [940 KB, uploaded 18 May 2012 08:52 CEST]
Abstract: The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
Keywords: antitumor therapy; vinblastine; vincristine; derivatives

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Keglevich, P.; Hazai, L.; Kalaus, G.; Szántay, C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules 2012, 17, 5893-5914.

AMA Style

Keglevich P, Hazai L, Kalaus G, Szántay C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules. 2012; 17(5):5893-5914.

Chicago/Turabian Style

Keglevich, Péter; Hazai, László; Kalaus, György; Szántay, Csaba. 2012. "Modifications on the Basic Skeletons of Vinblastine and Vincristine." Molecules 17, no. 5: 5893-5914.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert