Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Molecules 2012, 17(5), 5893-5914; doi:10.3390/molecules17055893
Review

Modifications on the Basic Skeletons of Vinblastine and Vincristine

, ,  and *
Received: 30 March 2012; in revised form: 9 May 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)
Download PDF [940 KB, uploaded 18 June 2014]
Abstract: The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
Keywords: antitumor therapy; vinblastine; vincristine; derivatives antitumor therapy; vinblastine; vincristine; derivatives
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Keglevich, P.; Hazai, L.; Kalaus, G.; Szántay, C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules 2012, 17, 5893-5914.

AMA Style

Keglevich P, Hazai L, Kalaus G, Szántay C. Modifications on the Basic Skeletons of Vinblastine and Vincristine. Molecules. 2012; 17(5):5893-5914.

Chicago/Turabian Style

Keglevich, Péter; Hazai, László; Kalaus, György; Szántay, Csaba. 2012. "Modifications on the Basic Skeletons of Vinblastine and Vincristine." Molecules 17, no. 5: 5893-5914.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert