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Molecules 2012, 17(5), 5882-5892; doi:10.3390/molecules17055882
Article

Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains

1, 2, 2, 3, 4, 1 and 2,*
Received: 12 April 2012; in revised form: 3 May 2012 / Accepted: 5 May 2012 / Published: 16 May 2012
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Abstract: 1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H-1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different Candida species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl)-1H-(1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.
Keywords: click chemistry; 1,2,3-triazoles; Candida spp.; antifungal activity click chemistry; 1,2,3-triazoles; Candida spp.; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lima-Neto, R.G.; Cavalcante, N.N.M.; Srivastava, R.M.; Mendonça Junior, F.J.B.; Wanderley, A.G.; Neves, R.P.; dos Anjos, J.V. Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains. Molecules 2012, 17, 5882-5892.

AMA Style

Lima-Neto RG, Cavalcante NNM, Srivastava RM, Mendonça Junior FJB, Wanderley AG, Neves RP, dos Anjos JV. Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains. Molecules. 2012; 17(5):5882-5892.

Chicago/Turabian Style

Lima-Neto, Reginaldo G.; Cavalcante, Nery N. M.; Srivastava, Rajendra M.; Mendonça Junior, Francisco J. B.; Wanderley, Almir G.; Neves, Rejane P.; dos Anjos, Janaína V. 2012. "Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains." Molecules 17, no. 5: 5882-5892.


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