Molecules 2011, 16(3), 2023-2031; doi:10.3390/molecules16032023
Article

Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds

Cledualdo Soares de Oliveira 1 email, Vivyanne Dos Santos Falcão-Silva 3 email, José Pinto Siqueira-Júnior 3 email, David Peter Harding 1 email, Bruno Freitas Lira 1 email, Jorge Gonçalo Fernandes Lorenzo 2 email, José Maria Barbosa-Filho 2 email and Petrônio Filgueiras de Athayde-Filho 1,* email
1 Department of Chemistry, Federal University of Paraíba, 58059, João Pessoa, PB, Brazil 2 Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051, João Pessoa, PB, Brazil 3 Department of Molecular Biology, Federal University of Paraíba, 58059, João Pessoa, PB, Brazil
* Author to whom correspondence should be addressed.
Received: 25 January 2011; in revised form: 19 February 2011 / Accepted: 22 February 2011 / Published: 28 February 2011
(This article belongs to the Special Issue Advances in Heterocyclic Chemistry)
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Abstract: Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.
Keywords: mesoionic compounds; modulation of drug resistance; efflux pump inhibitor

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MDPI and ACS Style

Soares de Oliveira, C.; Dos Santos Falcão-Silva, V.; Siqueira-Júnior, J.P.; Harding, D.P.; Lira, B.F.; Lorenzo, J.G.F.; Barbosa-Filho, J.M.; Filgueiras de Athayde-Filho, P. Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds. Molecules 2011, 16, 2023-2031.

AMA Style

Soares de Oliveira C, Dos Santos Falcão-Silva V, Siqueira-Júnior JP, Harding DP, Lira BF, Lorenzo JGF, Barbosa-Filho JM, Filgueiras de Athayde-Filho P. Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds. Molecules. 2011; 16(3):2023-2031.

Chicago/Turabian Style

Soares de Oliveira, Cledualdo; Dos Santos Falcão-Silva, Vivyanne; Siqueira-Júnior, José Pinto; Harding, David Peter; Lira, Bruno Freitas; Lorenzo, Jorge Gonçalo Fernandes; Barbosa-Filho, José Maria; Filgueiras de Athayde-Filho, Petrônio. 2011. "Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds." Molecules 16, no. 3: 2023-2031.

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