Molecules 2011, 16(3), 2023-2031; doi:10.3390/molecules16032023
Article

Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds

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Received: 25 January 2011; in revised form: 19 February 2011 / Accepted: 22 February 2011 / Published: 28 February 2011
(This article belongs to the Special Issue Advances in Heterocyclic Chemistry)
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Abstract: Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.
Keywords: mesoionic compounds; modulation of drug resistance; efflux pump inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Soares de Oliveira, C.; Dos Santos Falcão-Silva, V.; Siqueira-Júnior, J.P.; Harding, D.P.; Lira, B.F.; Lorenzo, J.G.F.; Barbosa-Filho, J.M.; Filgueiras de Athayde-Filho, P. Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds. Molecules 2011, 16, 2023-2031.

AMA Style

Soares de Oliveira C, Dos Santos Falcão-Silva V, Siqueira-Júnior JP, Harding DP, Lira BF, Lorenzo JGF, Barbosa-Filho JM, Filgueiras de Athayde-Filho P. Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds. Molecules. 2011; 16(3):2023-2031.

Chicago/Turabian Style

Soares de Oliveira, Cledualdo; Dos Santos Falcão-Silva, Vivyanne; Siqueira-Júnior, José Pinto; Harding, David Peter; Lira, Bruno Freitas; Lorenzo, Jorge Gonçalo Fernandes; Barbosa-Filho, José Maria; Filgueiras de Athayde-Filho, Petrônio. 2011. "Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds." Molecules 16, no. 3: 2023-2031.


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