Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

doi:10.3390/molecules17055497

This article is

freely available
re-usable

Molecules 2012, 17(5), 5497-5507; doi:10.3390/molecules17055497

Article

Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

Wen-Yan Li¹, Xu-Qiong Xiong¹, Dong-Mei Zhao^1,* , Yu-Fang Shi², Zhi-Heng Yang¹, Chao Yu¹, Pei-Wei Fan¹, Mao-Sheng Cheng¹ and Jing-Kang Shen^2,*

¹ Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China ² Central Research Institute, Shanghai Pharmaceuticals Holding Co., Ltd., Shanghai 201203, China

* Authors to whom correspondence should be addressed.

Received: 26 March 2012; in revised form: 14 April 2012 / Accepted: 20 April 2012 / Published: 9 May 2012

(This article belongs to the Section Medicinal Chemistry)

Download PDF Full-Text [248 KB, uploaded 9 May 2012 08:47 CEST]

Abstract: A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

Keywords: CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Li, W.-Y.; Xiong, X.-Q.; Zhao, D.-M.; Shi, Y.-F.; Yang, Z.-H.; Yu, C.; Fan, P.-W.; Cheng, M.-S.; Shen, J.-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules 2012, 17, 5497-5507.

AMA Style

Li W-Y, Xiong X-Q, Zhao D-M, Shi Y-F, Yang Z-H, Yu C, Fan P-W, Cheng M-S, Shen J-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules. 2012; 17(5):5497-5507.

Chicago/Turabian Style

Li, Wen-Yan; Xiong, Xu-Qiong; Zhao, Dong-Mei; Shi, Yu-Fang; Yang, Zhi-Heng; Yu, Chao; Fan, Pei-Wei; Cheng, Mao-Sheng; Shen, Jing-Kang. 2012. "Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors." Molecules 17, no. 5: 5497-5507.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert