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Molecules 2012, 17(5), 5497-5507; doi:10.3390/molecules17055497
Article

Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

1, 1, 1,* , 2, 1, 1, 1, 1 and 2,*
Received: 26 March 2012; in revised form: 14 April 2012 / Accepted: 20 April 2012 / Published: 9 May 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract: A series of novel quinoline-3-carboxamide derivatives 1017 and 2327 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
Keywords: CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, W.-Y.; Xiong, X.-Q.; Zhao, D.-M.; Shi, Y.-F.; Yang, Z.-H.; Yu, C.; Fan, P.-W.; Cheng, M.-S.; Shen, J.-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules 2012, 17, 5497-5507.

AMA Style

Li W-Y, Xiong X-Q, Zhao D-M, Shi Y-F, Yang Z-H, Yu C, Fan P-W, Cheng M-S, Shen J-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules. 2012; 17(5):5497-5507.

Chicago/Turabian Style

Li, Wen-Yan; Xiong, Xu-Qiong; Zhao, Dong-Mei; Shi, Yu-Fang; Yang, Zhi-Heng; Yu, Chao; Fan, Pei-Wei; Cheng, Mao-Sheng; Shen, Jing-Kang. 2012. "Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors." Molecules 17, no. 5: 5497-5507.



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