Molecules 2012, 17(5), 5497-5507; doi:10.3390/molecules17055497
Article

Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

1, 1, 1,* email, 2, 1, 1, 1, 1 and 2,* email
Received: 26 March 2012; in revised form: 14 April 2012 / Accepted: 20 April 2012 / Published: 9 May 2012
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of novel quinoline-3-carboxamide derivatives 1017 and 2327 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
Keywords: CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol
PDF Full-text Download PDF Full-Text [248 KB, uploaded 18 June 2014 19:48 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Li, W.-Y.; Xiong, X.-Q.; Zhao, D.-M.; Shi, Y.-F.; Yang, Z.-H.; Yu, C.; Fan, P.-W.; Cheng, M.-S.; Shen, J.-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules 2012, 17, 5497-5507.

AMA Style

Li W-Y, Xiong X-Q, Zhao D-M, Shi Y-F, Yang Z-H, Yu C, Fan P-W, Cheng M-S, Shen J-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules. 2012; 17(5):5497-5507.

Chicago/Turabian Style

Li, Wen-Yan; Xiong, Xu-Qiong; Zhao, Dong-Mei; Shi, Yu-Fang; Yang, Zhi-Heng; Yu, Chao; Fan, Pei-Wei; Cheng, Mao-Sheng; Shen, Jing-Kang. 2012. "Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors." Molecules 17, no. 5: 5497-5507.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert