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Molecules 2012, 17(4), 3618-3629; doi:10.3390/molecules17043618
Article

Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae

1,2, 1, 1, 2, 3, 1,*  and 4,*
1 Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine, Nanning 530011, China 2 College of Pharmacy, Hebei University, Baoding 071002, China 3 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 4 Department of Scientific Research, Guangxi University of Chinese Medicine, Nanning 530011, China
* Authors to whom correspondence should be addressed.
Received: 6 February 2012 / Revised: 6 March 2012 / Accepted: 15 March 2012 / Published: 23 March 2012
(This article belongs to the Section Metabolites)
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Abstract

A new method based on accelerated solvent extraction (ASE) combined with response surface methodology (RSM) modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill). The RSM method, based on a three level and three variable Box-Behnken design (BBD), was employed to obtain the optimal combination of extraction condition. In brief, the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally extracted with 87% ethanol as extraction solvent, extraction temperature of 160 °C, static extraction time of 10 min, extraction pressure of 1,500 psi, flush volume of 60% and one extraction cycle. The 3D response surface plot and the contour plot derived from the mathematical models were applied to determine the optimal conditions. Under the above conditions, the experimental value of four lignans was 14.72 mg/g, which is in close agreement with the value predicted by the model.
Keywords: accelerated solvent extraction; response surface methodology; lignans; Fructus Schisandrae accelerated solvent extraction; response surface methodology; lignans; Fructus Schisandrae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao, L.-C.; He, Y.; Deng, X.; Yang, G.-L.; Li, W.; Liang, J.; Tang, Q.-L. Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae. Molecules 2012, 17, 3618-3629.

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