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Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae
Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine, Nanning 530011, China
College of Pharmacy, Hebei University, Baoding 071002, China
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
Department of Scientific Research, Guangxi University of Chinese Medicine, Nanning 530011, China
* Authors to whom correspondence should be addressed.
Received: 6 February 2012; in revised form: 6 March 2012 / Accepted: 15 March 2012 / Published: 23 March 2012
Abstract: A new method based on accelerated solvent extraction (ASE) combined with response surface methodology (RSM) modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill). The RSM method, based on a three level and three variable Box-Behnken design (BBD), was employed to obtain the optimal combination of extraction condition. In brief, the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally extracted with 87% ethanol as extraction solvent, extraction temperature of 160 °C, static extraction time of 10 min, extraction pressure of 1,500 psi, flush volume of 60% and one extraction cycle. The 3D response surface plot and the contour plot derived from the mathematical models were applied to determine the optimal conditions. Under the above conditions, the experimental value of four lignans was 14.72 mg/g, which is in close agreement with the value predicted by the model.
Keywords: accelerated solvent extraction; response surface methodology; lignans; Fructus Schisandrae
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MDPI and ACS Style
Zhao, L.-C.; He, Y.; Deng, X.; Yang, G.-L.; Li, W.; Liang, J.; Tang, Q.-L. Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae. Molecules 2012, 17, 3618-3629.
Zhao L-C, He Y, Deng X, Yang G-L, Li W, Liang J, Tang Q-L. Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae. Molecules. 2012; 17(4):3618-3629.
Zhao, Li-Chun; He, Ying; Deng, Xin; Yang, Geng-Liang; Li, Wei; Liang, Jian; Tang, Qian-Li. 2012. "Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae." Molecules 17, no. 4: 3618-3629.