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Molecules 2012, 17(4), 3609-3617; doi:10.3390/molecules17043609
Article

Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats

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Received: 11 January 2012 / Revised: 3 March 2012 / Accepted: 12 March 2012 / Published: 23 March 2012
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Abstract

The body of tremella were decocted with water, and hydrolyzed with 0.1 mol/L hydrochloric acid for different times, giving tremella polysaccharides with six molecular mass values. The structures of all the tremella polysaccharides had non-reducing terminals of β-D-pyranglucuronide, the backbone was composed of (1→3)-linked β-D-manno-pyranoside, and the side chain composed of (1→6)-linked β-D-xylopyranoside was attached to the C2 of the backbone mannopyranoside. Immunomodulatory effect studies indicated that tremella polysaccharides increased the counts of leukocytes in the peripheral blood which were significantly lowered by cyclophosphamide, and the lower the molecular mass of the tremella polysaccharide, the better this effect was.
Keywords: tremella polysaccharide; hydrolysis; molecular mass; cyclophosphamide-induced leucopenia tremella polysaccharide; hydrolysis; molecular mass; cyclophosphamide-induced leucopenia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jiang, R.-Z.; Wang, Y.; Luo, H.-M.; Cheng, Y.-Q.; Chen, Y.-H.; Gao, Y.; Gao, Q.-P. Effect of the Molecular Mass of Tremella Polysaccharides on Accelerated Recovery from Cyclophosphamide-Induced Leucopenia in Rats. Molecules 2012, 17, 3609-3617.

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