Next Article in Journal
Relationship Between Wood Color Parameters Measured by the CIELab System and Extractive and Phenol Content in Acacia mangium and Vochysia guatemalensis from Fast-Growth Plantations
Previous Article in Journal
Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae
Molecules 2012, 17(4), 3630-3638; doi:10.3390/molecules17043630
Communication

Screening of Anti-Obesity Agent from Herbal Mixtures

* ,
 and
Received: 2 March 2012; in revised form: 19 March 2012 / Accepted: 21 March 2012 / Published: 23 March 2012
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [330 KB, uploaded 18 June 2014]   |   Browse Figures
Abstract: Globally, one in three of the World’s adults are overweight and one in 10 is obese. By 2015, World Health Organization (WHO) estimates the number of chubby adults will balloon to 2.3 billion—Equal to the combined populations of China, Europe and the United States. The discovery of bioactive compounds from herbs is one possible way to control obesity and to prevent or reduce the risks of developing various obesity-related diseases. In this study, we screened anti-obesity agents such as methyl gallate from the herbal composition known as HemoHIM that actively inhibits lipid formation as evidenced by Oil Red O staining and triglyceride (TG) contents in 3T3-L1 adipocytes, suggesting their use as an anti-obesity agent. Furthermore, the amount of glycerol released from cells into the medium had increased by treatment of methyl gallate in a concentration-dependent manner. The present study suggests that a promising anti-obesity agent like methyl gallate might be of therapeutic interest for the treatment of obesity.
Keywords: anti-obesity; screening; methyl gallate; HemoHIM; lipid inhibition anti-obesity; screening; methyl gallate; HemoHIM; lipid inhibition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Roh, C.; Jung, U.; Jo, S.-K. Screening of Anti-Obesity Agent from Herbal Mixtures. Molecules 2012, 17, 3630-3638.

AMA Style

Roh C, Jung U, Jo S-K. Screening of Anti-Obesity Agent from Herbal Mixtures. Molecules. 2012; 17(4):3630-3638.

Chicago/Turabian Style

Roh, Changhyun; Jung, Uhee; Jo, Sung-Kee. 2012. "Screening of Anti-Obesity Agent from Herbal Mixtures." Molecules 17, no. 4: 3630-3638.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert