Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(12), 14625-14636; doi:10.3390/molecules171214625
Article

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives

, *  and
Received: 16 October 2012; in revised form: 23 November 2012 / Accepted: 26 November 2012 / Published: 10 December 2012
Download PDF [199 KB, uploaded 18 June 2014]
Abstract: New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine. Also, some new heterocycles incorporating 1,3,4-thiadiazole ring were obtained by reaction of 1,3,4-thiadiazolenaminones 1 with nitrogen-nucleophiles like hydrazine hydrate, 3-amino-1,2,4-triazole and 2-aminobenzimidazole. The structure of the new products was established based on elemental and spectral analysis. The relation between the structure of the products and their activity towards some microorganisms was studied and promising results were obtained.
Keywords: antimicrobial activity; enaminone; 1,3,4-thiadiazole; hydrazonoyl halides antimicrobial activity; enaminone; 1,3,4-thiadiazole; hydrazonoyl halides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Farghaly, T.A.; Abdallah, M.A.; Aziz, M.R.A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives. Molecules 2012, 17, 14625-14636.

AMA Style

Farghaly TA, Abdallah MA, Aziz MRA. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives. Molecules. 2012; 17(12):14625-14636.

Chicago/Turabian Style

Farghaly, Thoraya A.; Abdallah, Magda A.; Aziz, Mohamed R.A. 2012. "Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives." Molecules 17, no. 12: 14625-14636.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert