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Molecules 2012, 17(12), 14099-14110; doi:10.3390/molecules171214099

Allylation of Functionalized Aldehydes by Potassium Allyltrifluoroborate Catalyzed by 18-Crown-6 in Aqueous Media

, , ,  and *
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n - Cidade Universitária, Recife – PE, 50740-560, Brazil
* Author to whom correspondence should be addressed.
Received: 25 September 2012 / Revised: 19 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Organic Synthesis)
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An efficient method for the allylation of aldehydes containing a broad range of functional groups using potassium allyltrifluoroborate is described. The reaction utilizes a catalytic amount of 18-C-6 in biphasic media under open atmosphere and room temperature to provide the corresponding homoallylic alcohols in high yields and without the necessity of any subsequent purification.
Keywords: potassium allyltrifluoroborate; allylation; 18-crown-6 potassium allyltrifluoroborate; allylation; 18-crown-6
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Barbosa, F.C.G.; Freitas, J.C.R.; Melo, C.F.; Menezes, P.H.; Oliveira, R.A. Allylation of Functionalized Aldehydes by Potassium Allyltrifluoroborate Catalyzed by 18-Crown-6 in Aqueous Media. Molecules 2012, 17, 14099-14110.

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