Molecules 2012, 17(12), 14091-14098; doi:10.3390/molecules171214091
Article

Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus

1 College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China 2 College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
* Authors to whom correspondence should be addressed.
Received: 16 October 2012; in revised form: 21 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Natural Products)
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Abstract: From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Keywords: antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L.

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MDPI and ACS Style

Miao, F.; Yang, R.; Chen, D.-D.; Wang, Y.; Qin, B.-F.; Yang, X.-J.; Zhou, L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules 2012, 17, 14091-14098.

AMA Style

Miao F, Yang R, Chen D-D, Wang Y, Qin B-F, Yang X-J, Zhou L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules. 2012; 17(12):14091-14098.

Chicago/Turabian Style

Miao, Fang; Yang, Rui; Chen, Dong-Dong; Wang, Ying; Qin, Bao-Fu; Yang, Xin-Juan; Zhou, Le. 2012. "Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus." Molecules 17, no. 12: 14091-14098.

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