Next Article in Journal
Allylation of Functionalized Aldehydes by Potassium Allyltrifluoroborate Catalyzed by 18-Crown-6 in Aqueous Media
Previous Article in Journal
Fluorescent Probes and Fluorescence (Microscopy) Techniques — Illuminating Biological and Biomedical Research
Molecules 2012, 17(12), 14091-14098; doi:10.3390/molecules171214091
Article

Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus

1, 2, 2, 1, 1, 1,2,*  and 2,*
1 College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China 2 College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
* Authors to whom correspondence should be addressed.
Received: 16 October 2012 / Revised: 21 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [204 KB, uploaded 18 June 2014]   |   Browse Figure

Abstract

From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Keywords: antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L. antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Miao, F.; Yang, R.; Chen, D.-D.; Wang, Y.; Qin, B.-F.; Yang, X.-J.; Zhou, L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules 2012, 17, 14091-14098.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert