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Molecules 2012, 17(12), 14091-14098; doi:10.3390/molecules171214091
Article

Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus

1, 2, 2, 1, 1, 1,2,*  and 2,*
Received: 16 October 2012; in revised form: 21 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Metabolites)
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Abstract: From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Keywords: antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L. antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Miao, F.; Yang, R.; Chen, D.-D.; Wang, Y.; Qin, B.-F.; Yang, X.-J.; Zhou, L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules 2012, 17, 14091-14098.

AMA Style

Miao F, Yang R, Chen D-D, Wang Y, Qin B-F, Yang X-J, Zhou L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules. 2012; 17(12):14091-14098.

Chicago/Turabian Style

Miao, Fang; Yang, Rui; Chen, Dong-Dong; Wang, Ying; Qin, Bao-Fu; Yang, Xin-Juan; Zhou, Le. 2012. "Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus." Molecules 17, no. 12: 14091-14098.



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