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Molecules 2012, 17(12), 14091-14098; doi:10.3390/molecules171214091

Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus

1
College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China
2
College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
*
Authors to whom correspondence should be addressed.
Received: 16 October 2012 / Revised: 21 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Natural Products)
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Abstract

From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Keywords: antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L. antimicrobial activity; isocoumarin; Talaromyces verruculosus; rhizosphere microorganism; Stellera chamaejasme L.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Miao, F.; Yang, R.; Chen, D.-D.; Wang, Y.; Qin, B.-F.; Yang, X.-J.; Zhou, L. Isolation, Identification and Antimicrobial Activities of Two Secondary Metabolites of Talaromyces verruculosus. Molecules 2012, 17, 14091-14098.

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