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The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
Department of Horticulture and Landscape Architecture, National Taiwan University, 1 Roosevelt Road Section 4, Taipei 10617, Taiwan
Institute of Food Science and Technology, National Taiwan University, 59 Roosevelt Road Section 4, Taipei 10617, Taiwan
Department of Science, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand
Department of Life Sciences, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan
* Author to whom correspondence should be addressed.
Received: 29 September 2012; in revised form: 27 October 2012 / Accepted: 29 October 2012 / Published: 1 November 2012
Abstract: Traditional or folk medicinal herbs continue to be prescribed in the treatment of various diseases and conditions in many cultures. Recent scientific efforts have focused on the potential roles of extracts of traditional herbs as alternative and complementary medications for cancer treatment. In Taiwan, Davallia divaricata Blume has been traditionally employed in folk medicine for therapy of lung cancer, davallic acid being the major active compound of D. divaricata Blume. In this study, we investigated the inhibitory activity of davallic acid on the proliferation of A549 lung cancer cells. Davallic acid was extracted from D. divaricata Blume, and its effects on cell viability, cell cycle distribution, ROS level, and apoptotic protein expression in A549 cells were determined. Davallic acid significantly induced reactive oxygen species (ROS) generation as well as caspase-3, -8, and -9 activation, thereby repressing A549 cell growth and elevating apoptotic activity. Since lung cancer has a high incidence of recurrence, these results indicate that davallic acid may have the potential to be a natural anti-lung cancer compound, and may provide a basis for further study of its use in combating cancer.
Keywords: Davallia divaricata Blume; davallic acid; lung cancer; apoptotic activity
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MDPI and ACS Style
Cheng, A.-S.; Chang, W.-C.; Cheng, Y.-H.; Chen, K.-Y.; Chen, K.-H.; Chang, T.-L. The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells. Molecules 2012, 17, 12938-12949.
Cheng A-S, Chang W-C, Cheng Y-H, Chen K-Y, Chen K-H, Chang T-L. The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells. Molecules. 2012; 17(11):12938-12949.
Cheng, An-Sheng; Chang, We-Chang; Cheng, Yu-Hsiang; Chen, Kai-Yu; Chen, Kai-Hsien; Chang, Tsu-Liang. 2012. "The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells." Molecules 17, no. 11: 12938-12949.