Molecules 2012, 17(11), 12950-12960; doi:10.3390/molecules171112950
Article

Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba

1, 2, 1, 1 and 1,* email
Received: 21 September 2012; in revised form: 6 October 2012 / Accepted: 19 October 2012 / Published: 1 November 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-N- oxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)- N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines.
Keywords: Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity
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MDPI and ACS Style

Zhang, W.; Hu, J.-F.; Lv, W.-W.; Zhao, Q.-C.; Shi, G.-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules 2012, 17, 12950-12960.

AMA Style

Zhang W, Hu J-F, Lv W-W, Zhao Q-C, Shi G-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules. 2012; 17(11):12950-12960.

Chicago/Turabian Style

Zhang, Wei; Hu, Jin-Feng; Lv, Wen-Wen; Zhao, Qing-Chun; Shi, Guo-Bing. 2012. "Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba." Molecules 17, no. 11: 12950-12960.

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