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Molecules 2012, 17(11), 12950-12960; doi:10.3390/molecules171112950
Article

Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba

1, 2, 1, 1 and 1,*
1 Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China 2 Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 21 September 2012 / Revised: 6 October 2012 / Accepted: 19 October 2012 / Published: 1 November 2012
(This article belongs to the Section Metabolites)
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Abstract

Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-N- oxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)- N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines.
Keywords: Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, W.; Hu, J.-F.; Lv, W.-W.; Zhao, Q.-C.; Shi, G.-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules 2012, 17, 12950-12960.

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