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Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba
Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Author to whom correspondence should be addressed.
Received: 21 September 2012; in revised form: 6 October 2012 / Accepted: 19 October 2012 / Published: 1 November 2012
Abstract: Five novel isoquinoline alkaloids (+)-N-(methoxylcarbonyl)-N-nordicentrin (1), (+)-N-(methoxylcarbonyl)-N-norpredicentrine (2), (+)-N-(methoxylcarbonyl)-N-norbulbodione (3), and (+)-N-(methoxylcarbonyl)-N-norisocorydione (4), and (+)-8-methoxyisolaurenine-N- oxide (5) were isolated, together with one known compound, (+)-N-(methoxylcarbonyl)- N-norglaucine (6), from a 70% EtOH extract of the barks of Litsea cubeba. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. Alkaloids 1, 2 and 6 showed antimicrobial activity against the bacterium S. aureus and two fungi (A. alternata and C. nicotianae). Compounds 3,4 exhibited significant cytotoxicity against all of six tested tumor cell lines.
Keywords: Litsea cubeba; Lauraceae; isoquinoline alkaloids; antibacterial; antifungal; cytotoxicity
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MDPI and ACS Style
Zhang, W.; Hu, J.-F.; Lv, W.-W.; Zhao, Q.-C.; Shi, G.-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules 2012, 17, 12950-12960.
Zhang W, Hu J-F, Lv W-W, Zhao Q-C, Shi G-B. Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba. Molecules. 2012; 17(11):12950-12960.
Zhang, Wei; Hu, Jin-Feng; Lv, Wen-Wen; Zhao, Qing-Chun; Shi, Guo-Bing. 2012. "Antibacterial, Antifungal and Cytotoxic Isoquinoline Alkaloids from Litsea cubeba." Molecules 17, no. 11: 12950-12960.