Molecules 2012, 17(10), 12393-12405; doi:10.3390/molecules171012393

trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness

1, 1, 2,* email, 3, 3, 3, 1 and 1
Received: 31 August 2012; in revised form: 13 September 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Methods in Polyphenol Analysis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits.
Keywords: resveratrol; food supplements; dietary supplements; nutraceuticals; quality control
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MDPI and ACS Style

Rossi, D.; Guerrini, A.; Bruni, R.; Brognara, E.; Borgatti, M.; Gambari, R.; Maietti, S.; Sacchetti, G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules 2012, 17, 12393-12405.

AMA Style

Rossi D, Guerrini A, Bruni R, Brognara E, Borgatti M, Gambari R, Maietti S, Sacchetti G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules. 2012; 17(10):12393-12405.

Chicago/Turabian Style

Rossi, Damiano; Guerrini, Alessandra; Bruni, Renato; Brognara, Eleonora; Borgatti, Monica; Gambari, Roberto; Maietti, Silvia; Sacchetti, Gianni. 2012. "trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness." Molecules 17, no. 10: 12393-12405.

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