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trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness
Dipartimento Scienze della Vita e Biotecnologie-SVEB, UR7 Terra&Acqua Tech-Università di Ferrara, Corso Ercole I d’Este 32, 44121 Ferrara, Italy
Dipartimento di Scienze degli Alimenti, Università di Parma, Viale G.P. Usberti 11A, I-43124 Parma, Italy
Dipartimento Scienze della Vita e Biotecnologie, Sezione Biochimica e Biologia Molecolare, Università di Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy
* Author to whom correspondence should be addressed.
Received: 31 August 2012; in revised form: 13 September 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
Abstract: Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits.
Keywords: resveratrol; food supplements; dietary supplements; nutraceuticals; quality control
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MDPI and ACS Style
Rossi, D.; Guerrini, A.; Bruni, R.; Brognara, E.; Borgatti, M.; Gambari, R.; Maietti, S.; Sacchetti, G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules 2012, 17, 12393-12405.
Rossi D, Guerrini A, Bruni R, Brognara E, Borgatti M, Gambari R, Maietti S, Sacchetti G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules. 2012; 17(10):12393-12405.
Rossi, Damiano; Guerrini, Alessandra; Bruni, Renato; Brognara, Eleonora; Borgatti, Monica; Gambari, Roberto; Maietti, Silvia; Sacchetti, Gianni. 2012. "trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness." Molecules 17, no. 10: 12393-12405.