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Molecules 2012, 17(10), 11920-11930; doi:10.3390/molecules171011920

Chemical Genetics — A Versatile Method to Combine Science and Higher Level Teaching in Molecular Genetics

Department of Biology-Genetics, Philipps-Universität Marburg, Karl-von-Frisch-Str. 8, 35043 Marburg, Germany
Received: 27 August 2012 / Revised: 26 September 2012 / Accepted: 28 September 2012 / Published: 9 October 2012
(This article belongs to the Special Issue Chemical Genetics)
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Phosphorylation is a key event in many cellular processes like cell cycle, transformation of environmental signals to transcriptional activation or polar growth. The chemical genetics approach can be used to analyse the effect of highly specific inhibition in vivo and is a promising method to screen for kinase targets. We have used this approach to study the role of the germinal centre kinase Don3 during the cell division in the phytopathogenic fungus Ustilago maydis. Due to the easy determination of the don3 phenotype we have chosen this approach for a genetic course for M.Sc. students and for IMPRS (International Max-Planck research school) students. According to the principle of “problem-based learning” the aim of this two-week course is to transfer knowledge about the broad spectrum of kinases to the students and that the students acquire the ability to design their own analog-sensitive kinase of interest. In addition to these training goals, we benefit from these annual courses the synthesis of basic constructs for genetic modification of several kinases in our model system U. maydis.
Keywords: U. maydis; chemical genetics; problem based learning; Don3as U. maydis; chemical genetics; problem based learning; Don3as
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Sandrock, B. Chemical Genetics — A Versatile Method to Combine Science and Higher Level Teaching in Molecular Genetics. Molecules 2012, 17, 11920-11930.

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