Molecules 2012, 17(8), 9258-9273; doi:10.3390/molecules17089258
Review

Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways

Jorrit M. Enserinkemail
Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, NO-0027 Oslo, Norway
Received: 26 June 2012; in revised form: 18 July 2012 / Accepted: 23 July 2012 / Published: 2 August 2012
(This article belongs to the Special Issue Chemical Genetics)
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Abstract: The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
Keywords: chemical-genetics; budding yeast; Saccharomyces cerevisiae; genetic interaction

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Cite This Article

MDPI and ACS Style

Enserink, J.M. Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways. Molecules 2012, 17, 9258-9273.

AMA Style

Enserink JM. Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways. Molecules. 2012; 17(8):9258-9273.

Chicago/Turabian Style

Enserink, Jorrit M. 2012. "Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways." Molecules 17, no. 8: 9258-9273.

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