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Molecules 2012, 17(8), 9258-9273; doi:10.3390/molecules17089258
Review

Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways

Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, NO-0027 Oslo, Norway
Received: 26 June 2012 / Revised: 18 July 2012 / Accepted: 23 July 2012 / Published: 2 August 2012
(This article belongs to the Special Issue Chemical Genetics)
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Abstract

The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
Keywords: chemical-genetics; budding yeast; Saccharomyces cerevisiae; genetic interaction chemical-genetics; budding yeast; Saccharomyces cerevisiae; genetic interaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Enserink, J.M. Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways. Molecules 2012, 17, 9258-9273.

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