Special Issue "Chemical Genetics"
QuicklinksA special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 31 August 2012
Special Issue Editor
Guest Editor
Dr. Richard YT Kao
Department of Microbiology, LKS Faculty of Medicine, The University of Hong Kong, L10-38, Laboratory Block, 21 Sassoon Road, Hong Kong
E-Mail: rytkao@hku.hk
Interests: chemical biology; chemical genetics; druggable targets; small molecule inhibitors; infectious diseases; antimicrobials; angiogenesis
Special Issue Information
Dear Colleagues,
Since its name being coined more than a decade ago, chemical genetics has been increasingly recognized as an effective technique in dissecting complicated biological processes difficult to be studied by conventional classical genetics approaches. The applications of chemical genetics are phenomenon and many disciplines such as cellular biology, cancer research, developmental biology, plant science, microbiology, drug discovery, etc., have been benefited greatly from this powerful methodology. New chemical compounds, probes, and novel screening procedures and informatics have been invented and applied to drive the rapid evolution of this powerful technique. This special issue on Chemical Genetics offers possibilities for colleagues to illustrate latest applications of chemical genetics in various disciplines and new technologies employed to enhance the capabilities of this evolving methodology.
Dr. Richard YT Kao
Guest Editor
Submission
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs) and starting from 1 July 2012, it is 1600 CHF.
Keywords
- chemical genetics
- chemical biology
- small molecule compounds
- inhibitors
- activators
- chemical probes
- informatics
- high-throughput Screening
- drug discovery
Published Papers
Planned Papers
Title: Chemical Genetics - a Versatile Tool to Combine Teaching and Science in Molecular Genetics
Author: Björn Sandrock
Affiliation: Philipps-Universität Marburg, Department of Biology – Genetics, Karl-von-Frisch-Str. 8, 35043 Marburg, Germany; E-Mail: sandrock@staff.uni-marburg.de
Abstract: Phosphorylation is a key event in many cellular processes like cell cycle, transformation of environmental signals to transcriptional activation or polar growth. The chemical genetics approach can be used to analyse the effect of highly specific inhibition in vivo and is an promising method to screen for kinase targets. We have used this approach to study the role of the germinal centre kinase Don3 during the cell division in the phytopathogenic fungus Ustilago maydis. Due to the easy determination of the don3 phenotype we have chosen this approach for a genetic course for MSc students and for IMPRS (International Max-Planck research school) students. The aim of this seven-day course is to transfer knowledge about the broad spectrum of kinases to the students and that the students acquire the ability to design their own analog-sensitive kinase of interest. In addition to these training goals, we benefit from these annual courses the basic constructs for genetic modification of several kinases in our model systme U. maydis.
Last update: 18 May 2012