Next Article in Journal
A New Triterpene from the Plant of Uncaria Macrophylla
Previous Article in Journal
A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters
Molecules 2012, 17(1), 492-503; doi:10.3390/molecules17010492
Article

Antimycobacterial Activity of Salicylanilide Benzenesulfonates

1
,
1,* , 1
 and
2
Received: 28 November 2011 / Revised: 29 December 2011 / Accepted: 2 January 2012 / Published: 5 January 2012
(This article belongs to the Section Medicinal Chemistry)
Download PDF [230 KB, uploaded 18 June 2014]

Abstract

A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, 1H-NMR and 13C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. In general, the minimum inhibitory concentrations range from 1 to 500 µmol/L. The most active compound against M. tuberculosis was 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)-phenyl benzenesulfonate, with MIC of 1 µmol/L and towards M. kansasii its isomer 5-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzenesulfonate (MIC of 2–4 µmol/L). M. avium was the less susceptible strain. However, generally, salicylanilide benzenesulfonates did not surpass the activity of other salicylanilide esters with carboxylic acids.
Keywords: antimycobacterial activity; benzenesulfonate; in vitro activity; salicylanilide ester antimycobacterial activity; benzenesulfonate; in vitro activity; salicylanilide ester
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Krátký, M.; Vinšová, J.; Rodriguez, N.G.; Stolaříková, J. Antimycobacterial Activity of Salicylanilide Benzenesulfonates. Molecules 2012, 17, 492-503.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert