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Antimycobacterial Activity of Salicylanilide Benzenesulfonates
AbstractA series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, 1H-NMR and 13C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. In general, the minimum inhibitory concentrations range from 1 to 500 µmol/L. The most active compound against M. tuberculosis was 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)-phenyl benzenesulfonate, with MIC of 1 µmol/L and towards M. kansasii its isomer 5-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzenesulfonate (MIC of 2–4 µmol/L). M. avium was the less susceptible strain. However, generally, salicylanilide benzenesulfonates did not surpass the activity of other salicylanilide esters with carboxylic acids.
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Krátký, M.; Vinšová, J.; Rodriguez, N.G.; Stolaříková, J. Antimycobacterial Activity of Salicylanilide Benzenesulfonates. Molecules 2012, 17, 492-503.View more citation formats
Krátký M, Vinšová J, Rodriguez NG, Stolaříková J. Antimycobacterial Activity of Salicylanilide Benzenesulfonates. Molecules. 2012; 17(1):492-503.Chicago/Turabian Style
Krátký, Martin; Vinšová, Jarmila; Rodriguez, Nabila Guisado; Stolaříková, Jiřina. 2012. "Antimycobacterial Activity of Salicylanilide Benzenesulfonates." Molecules 17, no. 1: 492-503.