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A New Triterpene from the Plant of Uncaria Macrophylla
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China
Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China
* Author to whom correspondence should be addressed.
Received: 27 November 2011; in revised form: 29 December 2011 / Accepted: 30 December 2011 / Published: 5 January 2012
Abstract: Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity.
Keywords: triterpene; 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester; Uncaria macrophylla; Rubiaceae; antitumor activity
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MDPI and ACS Style
Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene from the Plant of Uncaria Macrophylla. Molecules 2012, 17, 504-510.
Sun G, Zhang X, Xu X, Yang J, Zhong M, Yuan J. A New Triterpene from the Plant of Uncaria Macrophylla. Molecules. 2012; 17(1):504-510.
Sun, Guangli; Zhang, Xiaopo; Xu, Xudong; Yang, Junshan; Zhong, Mingliang; Yuan, Jingquan. 2012. "A New Triterpene from the Plant of Uncaria Macrophylla." Molecules 17, no. 1: 504-510.