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Molecules 2012, 17(1), 504-510; doi:10.3390/molecules17010504

A New Triterpene from the Plant of Uncaria Macrophylla

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2
Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China
3
Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China
*
Author to whom correspondence should be addressed.
Received: 27 November 2011 / Revised: 29 December 2011 / Accepted: 30 December 2011 / Published: 5 January 2012
(This article belongs to the Section Natural Products)
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Abstract

Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity.
Keywords: triterpene; 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester; Uncaria macrophylla; Rubiaceae; antitumor activity triterpene; 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester; Uncaria macrophylla; Rubiaceae; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene from the Plant of Uncaria Macrophylla. Molecules 2012, 17, 504-510.

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