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Molecules 2012, 17(1), 504-510; doi:10.3390/molecules17010504
Article

A New Triterpene from the Plant of Uncaria Macrophylla

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Received: 27 November 2011; in revised form: 29 December 2011 / Accepted: 30 December 2011 / Published: 5 January 2012
(This article belongs to the Section Metabolites)
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Abstract: Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity.
Keywords: triterpene; 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester; Uncaria macrophylla; Rubiaceae; antitumor activity triterpene; 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester; Uncaria macrophylla; Rubiaceae; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sun, G.; Zhang, X.; Xu, X.; Yang, J.; Zhong, M.; Yuan, J. A New Triterpene from the Plant of Uncaria Macrophylla. Molecules 2012, 17, 504-510.

AMA Style

Sun G, Zhang X, Xu X, Yang J, Zhong M, Yuan J. A New Triterpene from the Plant of Uncaria Macrophylla. Molecules. 2012; 17(1):504-510.

Chicago/Turabian Style

Sun, Guangli; Zhang, Xiaopo; Xu, Xudong; Yang, Junshan; Zhong, Mingliang; Yuan, Jingquan. 2012. "A New Triterpene from the Plant of Uncaria Macrophylla." Molecules 17, no. 1: 504-510.


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