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Molecules 2011, 16(9), 8053-8061; doi:10.3390/molecules16098053

A Short Synthesis of Bisabolane Sesquiterpenes

1,2,* , 1
1 College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China 2 Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
* Author to whom correspondence should be addressed.
Received: 31 August 2011 / Revised: 4 September 2011 / Accepted: 14 September 2011 / Published: 19 September 2011
(This article belongs to the Special Issue Terpenoids)
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A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
Keywords: curcumene; xanthorrhizol; curcuhydroquinone; synthesis curcumene; xanthorrhizol; curcuhydroquinone; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Du, Z.-T.; Zheng, S.; Chen, G.; Lv, D. A Short Synthesis of Bisabolane Sesquiterpenes. Molecules 2011, 16, 8053-8061.

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