Molecules 2011, 16(9), 8041-8052; doi:10.3390/molecules16098041

Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives

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Received: 26 July 2011; in revised form: 8 September 2011 / Accepted: 9 September 2011 / Published: 19 September 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shift differences in the 1H-NMR spectra.
Keywords: 1,4-dihydropyridines; bromination; nucleophilic substitution; hydrogen bond; NMR spectra; quantum chemical calculations
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MDPI and ACS Style

Petrova, M.; Muhamadejev, R.; Vigante, B.; Cekavicus, B.; Plotniece, A.; Duburs, G.; Liepinsh, E. Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives. Molecules 2011, 16, 8041-8052.

AMA Style

Petrova M, Muhamadejev R, Vigante B, Cekavicus B, Plotniece A, Duburs G, Liepinsh E. Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives. Molecules. 2011; 16(9):8041-8052.

Chicago/Turabian Style

Petrova, Marina; Muhamadejev, Ruslan; Vigante, Brigita; Cekavicus, Brigita; Plotniece, Aiva; Duburs, Gunars; Liepinsh, Edvards. 2011. "Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives." Molecules 16, no. 9: 8041-8052.

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