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Molecules 2011, 16(9), 8062-8075; doi:10.3390/molecules16098062

Effects of St John's Wort (Hypericum perforatum L.) Extracts on Epileptogenesis

1,* , 2
1 Laboratory of Neurophysiology, Department of Physiology, Medical Faculty, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia 2 Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia 3 University of Central Europe in Skalica, Královská 386/11, Skalica, 909 01 Trnavsky kraj, Slovakia
* Author to whom correspondence should be addressed.
Received: 22 August 2011 / Revised: 13 September 2011 / Accepted: 15 September 2011 / Published: 19 September 2011
(This article belongs to the Section Medicinal Chemistry)
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The purpose of this study was to investigate the effects of treatment with water, n-butanol and ether extracts of Hypercom perforatum L. on epileptogenesis in rabbits. Animals from the control group received solvent-ethanol, and the kindling model of epilepsy was used. Epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus. The following parameters were determined: the minimum current strength necessary to induce after-discharge (AD) – discharges appearing after cessation of stimulation; AD duration; the number of stimulations necessary to induce spontaneous kindling; and the latency time for the development of full kindling. The results obtained indicate that epileptogenesis is influenced by Hypericum perforatum L. extract treatment. Animals treated with an ether extract of Hypericum perforatum L. required significantly weaker minimum current strengths for the development of epileptogenic focus, and displayed longer AD times, while the number of electro-stimulations necessary for full kindling was less. In contrast, animals treated with water and n-butanol extracts required increased electro-stimulations for the development of epileptic discharge, and displayed shortened AD durations versus controls.
Keywords: St. John's wort; Hypericum perforatum L.; extracts; kindling; epilepsy; rabbits St. John's wort; Hypericum perforatum L.; extracts; kindling; epilepsy; rabbits
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ivetic, V.; Trivic, S.; Pogancev, M.K.; Popovic, M.; Zlinská, J. Effects of St John's Wort (Hypericum perforatum L.) Extracts on Epileptogenesis. Molecules 2011, 16, 8062-8075.

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