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Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review
Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic
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Received: 15 August 2011; in revised form: 5 September 2011 / Accepted: 9 September 2011 / Published: 15 September 2011
Abstract: β-Glucans are cell wall constituents of bacteria, yeast, fungi, and plants. They are not expressed in mammalian cells, but they are recognized by mammalian cells as pathogen-associated molecular patterns by pattern recognition receptors and thus act as biological response modifiers. This review summarizes data on the hematopoiesis-stimulating effects of β-glucans, as well as on their ability to enhance bone marrow recovery after an injury. β-Glucans have been shown to support murine hematopoiesis suppressed by ionizing radiation or cytotoxic anti-cancer therapy. They also enhance stem cell homing and engraftment. Basically, two forms of β-glucan preparations have been investigated, namely particulate and soluble ones. β-Glucans are generally well tolerated, the particulate forms showing a higher incidence of undesirable side effects. Taken together, the hematopoiesis-stimulating properties of β-glucans predetermine these biological response modifiers to ever increasing use in human medicinal practice.
Keywords: β-glucan; hematopoiesis; myelosuppression
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Hofer, M.; Pospíšil, M. Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review. Molecules 2011, 16, 7969-7979.
Hofer M, Pospíšil M. Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review. Molecules. 2011; 16(9):7969-7979.
Hofer, Michal; Pospíšil, Milan. 2011. "Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review." Molecules 16, no. 9: 7969-7979.