Abstract: Staphylococcus aureus causes a broad range of life-threatening diseases in humans. The pathogenicity of this micro-organism is largely dependent upon its virulence factors. One of the most extensively studied virulence factors is the extracellular protein α-toxin. In this study, we show that allicin, an organosulfur compound, was active against S. aureus with MICs ranged from 32 to 64 μg/mL. Haemolysis, Western blot and real-time RT-PCR assays were used to evaluate the effects of allicin on S. aureus α-toxin production and on the levels of gene expression, respectively. The results of our study indicated that sub-inhibitory concentrations of allicin decreased the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) in a dose-dependent manner. Furthermore, the transcriptional levels of agr (accessory gene regulator) in S. aureus were inhibited by allicin. Therefore, allicin may be useful in the treatment of α-toxin-producing S. aureus infections.
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Leng, B.-F.; Qiu, J.-Z.; Dai, X.-H.; Dong, J.; Wang, J.-F.; Luo, M.-J.; Li, H.-E.; Niu, X.-D.; Zhang, Y.; Ai, Y.-X.; Deng, X.-M. Allicin Reduces the Production of α-Toxin by Staphylococcus aureus. Molecules 2011, 16, 7958-7968.
Leng B-F, Qiu J-Z, Dai X-H, Dong J, Wang J-F, Luo M-J, Li H-E, Niu X-D, Zhang Y, Ai Y-X, Deng X-M. Allicin Reduces the Production of α-Toxin by Staphylococcus aureus. Molecules. 2011; 16(9):7958-7968.
Leng, Bing-Feng; Qiu, Jia-Zhang; Dai, Xiao-Han; Dong, Jing; Wang, Jian-Feng; Luo, Ming-Jing; Li, Hong-En; Niu, Xiao-Di; Zhang, Yu; Ai, Yong-Xing; Deng, Xu-Ming. 2011. "Allicin Reduces the Production of α-Toxin by Staphylococcus aureus." Molecules 16, no. 9: 7958-7968.