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Allicin Reduces the Production of α-Toxin by Staphylococcus aureus
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China
College of Quartermaster Technology, Jilin University, Changchun 130062, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 20 July 2011; in revised form: 1 September 2011 / Accepted: 7 September 2011 / Published: 15 September 2011
Abstract: Staphylococcus aureus causes a broad range of life-threatening diseases in humans. The pathogenicity of this micro-organism is largely dependent upon its virulence factors. One of the most extensively studied virulence factors is the extracellular protein α-toxin. In this study, we show that allicin, an organosulfur compound, was active against S. aureus with MICs ranged from 32 to 64 μg/mL. Haemolysis, Western blot and real-time RT-PCR assays were used to evaluate the effects of allicin on S. aureus α-toxin production and on the levels of gene expression, respectively. The results of our study indicated that sub-inhibitory concentrations of allicin decreased the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) in a dose-dependent manner. Furthermore, the transcriptional levels of agr (accessory gene regulator) in S. aureus were inhibited by allicin. Therefore, allicin may be useful in the treatment of α-toxin-producing S. aureus infections.
Keywords: Staphylococcus aureus; α-toxin; allicin; sub-inhibitory concentrations
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Leng, B.-F.; Qiu, J.-Z.; Dai, X.-H.; Dong, J.; Wang, J.-F.; Luo, M.-J.; Li, H.-E.; Niu, X.-D.; Zhang, Y.; Ai, Y.-X.; Deng, X.-M. Allicin Reduces the Production of α-Toxin by Staphylococcus aureus. Molecules 2011, 16, 7958-7968.
Leng B-F, Qiu J-Z, Dai X-H, Dong J, Wang J-F, Luo M-J, Li H-E, Niu X-D, Zhang Y, Ai Y-X, Deng X-M. Allicin Reduces the Production of α-Toxin by Staphylococcus aureus. Molecules. 2011; 16(9):7958-7968.
Leng, Bing-Feng; Qiu, Jia-Zhang; Dai, Xiao-Han; Dong, Jing; Wang, Jian-Feng; Luo, Ming-Jing; Li, Hong-En; Niu, Xiao-Di; Zhang, Yu; Ai, Yong-Xing; Deng, Xu-Ming. 2011. "Allicin Reduces the Production of α-Toxin by Staphylococcus aureus." Molecules 16, no. 9: 7958-7968.