Molecules 2011, 16(9), 7815-7843; doi:10.3390/molecules16097815
Review

Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives

1,* email, 2,* email and 1
Received: 15 August 2011; in revised form: 5 September 2011 / Accepted: 8 September 2011 / Published: 13 September 2011
(This article belongs to the Special Issue Gold Catalysts)
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Abstract: The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.
Keywords: gold catalysis; alkynols; total synthesis; natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alcaide, B.; Almendros, P.; Alonso, J.M. Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives. Molecules 2011, 16, 7815-7843.

AMA Style

Alcaide B, Almendros P, Alonso JM. Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives. Molecules. 2011; 16(9):7815-7843.

Chicago/Turabian Style

Alcaide, Benito; Almendros, Pedro; Alonso, José M. 2011. "Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives." Molecules 16, no. 9: 7815-7843.


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