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Molecules 2011, 16(9), 7815-7843; doi:10.3390/molecules16097815

Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives

1
Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica I, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain
2
Instituto de Química Orgánica General, CSIC, Juan de la Cierva 3, 28006-Madrid, Spain
*
Authors to whom correspondence should be addressed.
Received: 15 August 2011 / Revised: 5 September 2011 / Accepted: 8 September 2011 / Published: 13 September 2011
(This article belongs to the Special Issue Gold Catalysts)
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Abstract

The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.
Keywords: gold catalysis; alkynols; total synthesis; natural products gold catalysis; alkynols; total synthesis; natural products
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Alcaide, B.; Almendros, P.; Alonso, J.M. Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives. Molecules 2011, 16, 7815-7843.

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