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Molecules 2011, 16(9), 7608-7620; doi:10.3390/molecules16097608
Article

Studies on the Electrochemical Behavior of Thiazolidine and Its Applications Using a Flow–Through Chronoamperometric Sensor Based on a Gold Electrode

*  and
Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Jen Te, Tainan 71743, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 July 2011 / Revised: 30 August 2011 / Accepted: 1 September 2011 / Published: 6 September 2011
(This article belongs to the Special Issue Gold Catalysts)
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Abstract

The electrochemical behaviors of thiazolidine (tetrahydrothiazole) on gold and platinum electrodes were investigated in a Britton-Robinson buffer (pH 2.77–11.61), acetate buffer (pH 4.31), phosphate buffer solutions (pH 2.11 and 6.38) and methanol or acetonitrile containing various supporting electrolytes. Detection was based on a gold wire electrochemical signal obtained with a supporting electrolyte containing 20% methanol-1.0 mM of phosphate buffer (pH 6.87, potassium dihydrogen phosphate and dipotassium hydrogen phosphate) as the mobile phase. Comparison with results obtained with a commercial amperometric detector shows good agreement. Using the chronoamperometric sensor with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.05 to 16 mg L−1 was found. The limit of quantification (LOQ) of the method for thiazolidine was found to be 1 ng.
Keywords: electrochemical behavior; thiazolidine; chronoamperometric sensor; gold electrode electrochemical behavior; thiazolidine; chronoamperometric sensor; gold electrode
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, L.-H.; Li, W.-J. Studies on the Electrochemical Behavior of Thiazolidine and Its Applications Using a Flow–Through Chronoamperometric Sensor Based on a Gold Electrode. Molecules 2011, 16, 7608-7620.

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