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Molecules 2011, 16(9), 7608-7620; doi:10.3390/molecules16097608
Article

Studies on the Electrochemical Behavior of Thiazolidine and Its Applications Using a Flow–Through Chronoamperometric Sensor Based on a Gold Electrode

*  and
Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Jen Te, Tainan 71743, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 July 2011 / Revised: 30 August 2011 / Accepted: 1 September 2011 / Published: 6 September 2011
(This article belongs to the Special Issue Gold Catalysts)
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Abstract

The electrochemical behaviors of thiazolidine (tetrahydrothiazole) on gold and platinum electrodes were investigated in a Britton-Robinson buffer (pH 2.77–11.61), acetate buffer (pH 4.31), phosphate buffer solutions (pH 2.11 and 6.38) and methanol or acetonitrile containing various supporting electrolytes. Detection was based on a gold wire electrochemical signal obtained with a supporting electrolyte containing 20% methanol-1.0 mM of phosphate buffer (pH 6.87, potassium dihydrogen phosphate and dipotassium hydrogen phosphate) as the mobile phase. Comparison with results obtained with a commercial amperometric detector shows good agreement. Using the chronoamperometric sensor with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.05 to 16 mg L−1 was found. The limit of quantification (LOQ) of the method for thiazolidine was found to be 1 ng.
Keywords: electrochemical behavior; thiazolidine; chronoamperometric sensor; gold electrode electrochemical behavior; thiazolidine; chronoamperometric sensor; gold electrode
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, L.-H.; Li, W.-J. Studies on the Electrochemical Behavior of Thiazolidine and Its Applications Using a Flow–Through Chronoamperometric Sensor Based on a Gold Electrode. Molecules 2011, 16, 7608-7620.

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