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Molecules 2011, 16(9), 7621-7626; doi:10.3390/molecules16097621
Communication

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

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Received: 11 August 2011 / Revised: 24 August 2011 / Accepted: 31 August 2011 / Published: 6 September 2011
(This article belongs to the Special Issue Fluorine Chemistry)
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Abstract

4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [18F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [18F]fluoride with subsequent deprotection is described, yielding n.c.a. [18F]fluorophenol in 34 to 36% radiochemical yield.
Keywords: fluorine-18; 4-[18F]fluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography fluorine-18; 4-[18F]fluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ross, T.L.; Ermert, J.; Coenen, H.H. Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide. Molecules 2011, 16, 7621-7626.

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