Molecules 2011, 16(9), 7621-7626; doi:10.3390/molecules16097621
Communication

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany Current address: Institute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.
* Author to whom correspondence should be addressed.
Received: 11 August 2011; in revised form: 24 August 2011 / Accepted: 31 August 2011 / Published: 6 September 2011
(This article belongs to the Special Issue Fluorine Chemistry)
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Abstract: 4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [18F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [18F]fluoride with subsequent deprotection is described, yielding n.c.a. [18F]fluorophenol in 34 to 36% radiochemical yield.
Keywords: fluorine-18; 4-[18F]fluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography

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MDPI and ACS Style

Ross, T.L.; Ermert, J.; Coenen, H.H. Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide. Molecules 2011, 16, 7621-7626.

AMA Style

Ross TL, Ermert J, Coenen HH. Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide. Molecules. 2011; 16(9):7621-7626.

Chicago/Turabian Style

Ross, Tobias L.; Ermert, Johannes; Coenen, Heinz H. 2011. "Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide." Molecules 16, no. 9: 7621-7626.

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