Next Article in Journal
Previous Article in Journal
Molecules 2011, 16(9), 7627-7633; doi:10.3390/molecules16097627
Communication

Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride

1,* , 2, 3 and 3
Received: 29 July 2011; in revised form: 22 August 2011 / Accepted: 25 August 2011 / Published: 6 September 2011
Download PDF [484 KB, uploaded 18 June 2014]
Abstract: In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1H-indole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) Å, b 107.702(7)°, V 1723.2(9) Å3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°].
Keywords: indole; pyridinium salt; X-ray crystal structure indole; pyridinium salt; X-ray crystal structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Bremner, J.B.; Samosorn, S.; Skelton, B.W.; White, A.H. Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride. Molecules 2011, 16, 7627-7633.

AMA Style

Bremner JB, Samosorn S, Skelton BW, White AH. Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride. Molecules. 2011; 16(9):7627-7633.

Chicago/Turabian Style

Bremner, John B.; Samosorn, Siritron; Skelton, Brian W.; White, Allan H. 2011. "Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride." Molecules 16, no. 9: 7627-7633.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert