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Molecules 2011, 16(9), 8083-8097; doi:10.3390/molecules16098083
Article

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

* , ,  and
Received: 1 August 2011; in revised form: 9 September 2011 / Accepted: 16 September 2011 / Published: 20 September 2011
(This article belongs to the Special Issue Fluorine Chemistry)
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Abstract: A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.
Keywords: malaria; sulfonamide; trifluoromethyl; dihydropteroate synthase; DHPS malaria; sulfonamide; trifluoromethyl; dihydropteroate synthase; DHPS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Boechat, N.; Pinheiro, L.C.; Santos-Filho, O.A.; Silva, I.C. Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes. Molecules 2011, 16, 8083-8097.

AMA Style

Boechat N, Pinheiro LC, Santos-Filho OA, Silva IC. Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes. Molecules. 2011; 16(9):8083-8097.

Chicago/Turabian Style

Boechat, Nubia; Pinheiro, Luiz C.S.; Santos-Filho, Osvaldo A.; Silva, Isabor C. 2011. "Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes." Molecules 16, no. 9: 8083-8097.


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