Molecules 2011, 16(8), 6747-6757; doi:10.3390/molecules16086747
Article

Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

Toshiki Nakano 1 , Yusuke Yagi 2 , Mizuki Miyahara 2 , Akio Kaminura 1,* email, Motoi Kawatsura 2  and Toshiyuki Itoh 2,* email
1 Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, 2-16-1 Tokiwadai, Ube 755-8611, Japan 2 Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan
* Authors to whom correspondence should be addressed.
Received: 4 July 2011; in revised form: 2 August 2011 / Accepted: 4 August 2011 / Published: 9 August 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
PDF Full-text Download PDF Full-Text [255 KB, uploaded 9 August 2011 13:54 CEST]
Abstract: Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.
Keywords: nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Nakano, T.; Yagi, Y.; Miyahara, M.; Kaminura, A.; Kawatsura, M.; Itoh, T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules 2011, 16, 6747-6757.

AMA Style

Nakano T, Yagi Y, Miyahara M, Kaminura A, Kawatsura M, Itoh T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules. 2011; 16(8):6747-6757.

Chicago/Turabian Style

Nakano, Toshiki; Yagi, Yusuke; Miyahara, Mizuki; Kaminura, Akio; Kawatsura, Motoi; Itoh, Toshiyuki. 2011. "Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds." Molecules 16, no. 8: 6747-6757.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert