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Molecules 2011, 16(8), 6747-6757; doi:10.3390/molecules16086747
Article

Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

1, 2, 2, 1,* , 2 and 2,*
1 Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, 2-16-1 Tokiwadai, Ube 755-8611, Japan 2 Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan
* Authors to whom correspondence should be addressed.
Received: 4 July 2011 / Revised: 2 August 2011 / Accepted: 4 August 2011 / Published: 9 August 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Abstract

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.
Keywords: nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nakano, T.; Yagi, Y.; Miyahara, M.; Kaminura, A.; Kawatsura, M.; Itoh, T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules 2011, 16, 6747-6757.

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