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Molecules 2011, 16(8), 6747-6757; doi:10.3390/molecules16086747
Article

Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

1, 2, 2, 1,* , 2 and 2,*
Received: 4 July 2011; in revised form: 2 August 2011 / Accepted: 4 August 2011 / Published: 9 August 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Abstract: Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.
Keywords: nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nakano, T.; Yagi, Y.; Miyahara, M.; Kaminura, A.; Kawatsura, M.; Itoh, T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules 2011, 16, 6747-6757.

AMA Style

Nakano T, Yagi Y, Miyahara M, Kaminura A, Kawatsura M, Itoh T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules. 2011; 16(8):6747-6757.

Chicago/Turabian Style

Nakano, Toshiki; Yagi, Yusuke; Miyahara, Mizuki; Kaminura, Akio; Kawatsura, Motoi; Itoh, Toshiyuki. 2011. "Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds." Molecules 16, no. 8: 6747-6757.



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