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Molecules 2011, 16(8), 6747-6757; doi:10.3390/molecules16086747
Article

Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

1, 2, 2, 1,* , 2 and 2,*
1 Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, 2-16-1 Tokiwadai, Ube 755-8611, Japan 2 Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan
* Authors to whom correspondence should be addressed.
Received: 4 July 2011 / Revised: 2 August 2011 / Accepted: 4 August 2011 / Published: 9 August 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Abstract

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.
Keywords: nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis nitro alcohol; quaternary chiral carbon; lipase; optically active; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nakano, T.; Yagi, Y.; Miyahara, M.; Kaminura, A.; Kawatsura, M.; Itoh, T. Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds. Molecules 2011, 16, 6747-6757.

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