Molecules 2011, 16(8), 6634-6644; doi:10.3390/molecules16086634
Article

Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil

Hossein Jahangirian 1,* email, Md Jelas Haron 1,* email, Nor Azah Yusof 1 , Sidik Silong 1 , Anuar Kassim 1 , Roshanak Rafiee-Moghaddam 2 , Mazyar Peyda 3  and Yadollah Gharayebi 1
1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia 2 School of Chemical Sciences and food Technology, Faculty of science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, Malaysia 3 Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia
* Authors to whom correspondence should be addressed.
Received: 20 June 2011; in revised form: 19 July 2011 / Accepted: 19 July 2011 / Published: 5 August 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Abstract: Fatty hydroxamic acid derivatives were synthesized using Lipozyme TL IM catalyst at biphasic medium as the palm kernel oil was dissolved in hexane and hydroxylamine derivatives were dissolved in water: (1) N-methyl fatty hydroxamic acids (MFHAs); (2) N-isopropyl fatty hydroxamic acids (IPFHAs) and (3) N-benzyl fatty hydroxamic acids (BFHAs) were synthesized by reaction of palm kernel oil and N-methyl hydroxylamine (N-MHA), N-isopropyl hydroxylamine (N-IPHA) and N-benzyl hydroxylamine (N-BHA), respectively. Finally, after separation the products were characterized by color testing, elemental analysis, FT-IR and 1H-NMR spectroscopy. For achieving the highest conversion percentage of product the optimum molar ratio of reactants was obtained by changing the ratio of reactants while other reaction parameters were kept constant. For synthesis of MFHAs the optimum mol ratio of N-MHA/palm kernel oil = 6/1 and the highest conversion was 77.8%, for synthesis of IPFHAs the optimum mol ratio of N-IPHA/palm kernel oil = 7/1 and the highest conversion was 65.4% and for synthesis of BFHAs the optimum mol ratio of N-BHA/palm kernel oil = 7/1 and the highest conversion was 61.7%.
Keywords: benzyl fatty hydroxamic acids; methyl fatty hydroxamic acids; isopropyl fatty hydroxamic acids; enzymatic reaction; palm kernel oil; lipozyme

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Cite This Article

MDPI and ACS Style

Jahangirian, H.; Haron, M.J.; Yusof, N.A.; Silong, S.; Kassim, A.; Rafiee-Moghaddam, R.; Peyda, M.; Gharayebi, Y. Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil. Molecules 2011, 16, 6634-6644.

AMA Style

Jahangirian H, Haron MJ, Yusof NA, Silong S, Kassim A, Rafiee-Moghaddam R, Peyda M, Gharayebi Y. Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil. Molecules. 2011; 16(8):6634-6644.

Chicago/Turabian Style

Jahangirian, Hossein; Haron, Md Jelas; Yusof, Nor Azah; Silong, Sidik; Kassim, Anuar; Rafiee-Moghaddam, Roshanak; Peyda, Mazyar; Gharayebi, Yadollah. 2011. "Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil." Molecules 16, no. 8: 6634-6644.

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