Molecules 2011, 16(8), 6313-6321; doi:10.3390/molecules16086313
Communication

A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

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Received: 1 July 2011; in revised form: 19 July 2011 / Accepted: 22 July 2011 / Published: 26 July 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
Keywords: 4-arylcoumarins; Kostanecki reaction; DBU; 3,4-disubstituted coumarins; one-pot reaction
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MDPI and ACS Style

Hwang, I.-T.; Lee, S.-A.; Hwang, J.-S.; Lee, K.-I. A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU. Molecules 2011, 16, 6313-6321.

AMA Style

Hwang I-T, Lee S-A, Hwang J-S, Lee K-I. A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU. Molecules. 2011; 16(8):6313-6321.

Chicago/Turabian Style

Hwang, In-Taek; Lee, Sun-Ah; Hwang, Jin-Soo; Lee, Kee-In. 2011. "A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU." Molecules 16, no. 8: 6313-6321.

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