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Molecules 2011, 16(8), 6313-6321; doi:10.3390/molecules16086313
Communication

A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

, ,  and *
Green Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Taejon 305-600, Korea
* Author to whom correspondence should be addressed.
Received: 1 July 2011 / Revised: 19 July 2011 / Accepted: 22 July 2011 / Published: 26 July 2011
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Abstract

An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
Keywords: 4-arylcoumarins; Kostanecki reaction; DBU; 3,4-disubstituted coumarins; one-pot reaction 4-arylcoumarins; Kostanecki reaction; DBU; 3,4-disubstituted coumarins; one-pot reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hwang, I.-T.; Lee, S.-A.; Hwang, J.-S.; Lee, K.-I. A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU. Molecules 2011, 16, 6313-6321.

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