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Molecules 2011, 16(8), 6306-6312; doi:10.3390/molecules16086306

Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties

Department of Chemistry, FI-40014 University of Jyväskylä, Finland
Author to whom correspondence should be addressed.
Received: 1 July 2011 / Revised: 18 July 2011 / Accepted: 25 July 2011 / Published: 26 July 2011
(This article belongs to the Special Issue Steroids)
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The reaction of 3-aminopropylamide of cholic acid with CS2 produced a bile acid derivative of dithiocarbamic acid which further formed an ammonium salt with another molecule of 3-aminopropylamide of cholic acid. The cationic 3-ammonium propylamide of cholic acid did not react further with CS2 and the formed salt was stable in the reaction mixture, even when excess CS2 was used. When the reaction was carried out in the presence of aqueous sodium hydroxide, only the bile acid derivative of sodium dithiocarbamate was formed. The dithiocarbamate derivatives were characterized by 1H- and 13C-NMR spectroscopy and ESI-TOF mass spectrometry.
Keywords: cholic acid; dithiocarbamate; steroid; NMR spectroscopy; amine cholic acid; dithiocarbamate; steroid; NMR spectroscopy; amine

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Koivukorpi, J.; Kolehmainen, E. Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties. Molecules 2011, 16, 6306-6312.

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