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Molecules 2011, 16(8), 6206-6214; doi:10.3390/molecules16086206
Article

New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia

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1 Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China 2 School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China 3 Institute of Traditional Chinese Medicine and Natural products, Jinan University, Guangzhou 510632, China 4 Key Lab for Research & Development of New Drugs, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China 5 Institute of Basic Medical Sciences, Beijing 100850, China
* Author to whom correspondence should be addressed.
Received: 27 June 2011 / Revised: 12 July 2011 / Accepted: 21 July 2011 / Published: 25 July 2011
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Abstract

Seven 3′,8′′-linked bioflavonoids, including one new compound, (2′′S)-2′′, 3′′-dihydroamentoflavone-4′-methyl ether (1) and six known compounds: (2S)-2,3- dihydroamentoflavone-4′-methyl ether (2), (2S,2′′S)-2,3,2′′,3′′-tetrahydroamento- flavone-4′-methyl ether (3), (2S,2′′S)-tetrahydroamentoflavone (4), (2S)-2,3-dihydro- amentoflavone (5) and (2′′S)-2′′,3′′-dihydroamentoflavone (6) and amentoflavone (7), were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.
Keywords: Selaginella uncinata (Desv.) Spring; 3′,8′′-linked biflavonoids; protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether Selaginella uncinata (Desv.) Spring; 3′,8′′-linked biflavonoids; protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zheng, J.-X.; Zheng, Y.; Zhi, H.; Dai, Y.; Wang, N.-L.; Fang, Y.-X.; Du, Z.-Y.; Zhang, K.; Li, M.-M.; Wu, L.-Y.; Fan, M. New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia. Molecules 2011, 16, 6206-6214.

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