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Molecules 2011, 16(8), 6206-6214; doi:10.3390/molecules16086206
Article

New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia

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Received: 27 June 2011; in revised form: 12 July 2011 / Accepted: 21 July 2011 / Published: 25 July 2011
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Abstract: Seven 3′,8′′-linked bioflavonoids, including one new compound, (2′′S)-2′′, 3′′-dihydroamentoflavone-4′-methyl ether (1) and six known compounds: (2S)-2,3- dihydroamentoflavone-4′-methyl ether (2), (2S,2′′S)-2,3,2′′,3′′-tetrahydroamento- flavone-4′-methyl ether (3), (2S,2′′S)-tetrahydroamentoflavone (4), (2S)-2,3-dihydro- amentoflavone (5) and (2′′S)-2′′,3′′-dihydroamentoflavone (6) and amentoflavone (7), were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.
Keywords: Selaginella uncinata (Desv.) Spring; 3′,8′′-linked biflavonoids; protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether Selaginella uncinata (Desv.) Spring; 3′,8′′-linked biflavonoids; protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zheng, J.-X.; Zheng, Y.; Zhi, H.; Dai, Y.; Wang, N.-L.; Fang, Y.-X.; Du, Z.-Y.; Zhang, K.; Li, M.-M.; Wu, L.-Y.; Fan, M. New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia. Molecules 2011, 16, 6206-6214.

AMA Style

Zheng J-X, Zheng Y, Zhi H, Dai Y, Wang N-L, Fang Y-X, Du Z-Y, Zhang K, Li M-M, Wu L-Y, Fan M. New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia. Molecules. 2011; 16(8):6206-6214.

Chicago/Turabian Style

Zheng, Jun-Xia; Zheng, Yang; Zhi, Hui; Dai, Yi; Wang, Nai-Li; Fang, Yan-Xiong; Du, Zhi-Yun; Zhang, Kun; Li, Ming-Ming; Wu, Li-Ying; Fan, Ming. 2011. "New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia." Molecules 16, no. 8: 6206-6214.


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