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Molecules 2011, 16(8), 6179-6192; doi:10.3390/molecules16086179

Antioxidant Activity of Papaya Seed Extracts

1,2, 1, 1, 1, 1 and 1,*
1 Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China 2 The Institute of Tropical Bioscience & Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China
* Author to whom correspondence should be addressed.
Received: 27 June 2011 / Revised: 18 July 2011 / Accepted: 19 July 2011 / Published: 25 July 2011
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The antioxidant activities of the ethanol, petroleum ether, ethyl acetate, n-butanol and water extract fractions from the seeds of papaya were evaluated in this study. The ethyl acetate fraction showed the strongest DPPH and hydroxyl free radical-scavenging activities, and its activities were stronger than those of ascorbic acid and sodium benzoate, respectively. The n-butanol fraction demonstrated the greatest ABTS+ radicals scavenging activity. The ethyl acetate fraction and the n-butanol fraction not only showed higher antioxidant activities than the petroleum ether fraction, water fraction and ethanol fraction, but also showed higher superoxide anion and hydrogen peroxide radicals scavenging activities than those of the other extract fractions. The high amount of total phenolics and total flavonoids in the ethyl acetate and n-butanol fractions contributed to their antioxidant activities. The ethyl acetate fraction was subjected to column chromatography, to yield two phenolic compounds, p-hydroxybenzoic acid (1) and vanillic acid (2), which possessed significant antioxidant activities. Therefore, the seeds of papaya and these compounds might be used as natural antioxidants.
Keywords: papaya; seeds; antioxidant activity; radical scavenging activities
papaya; seeds; antioxidant activity; radical scavenging activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhou, K.; Wang, H.; Mei, W.; Li, X.; Luo, Y.; Dai, H. Antioxidant Activity of Papaya Seed Extracts. Molecules 2011, 16, 6179-6192.

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