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Molecules 2011, 16(7), 6010-6022; doi:10.3390/molecules16076010
Article

Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells

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School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
* Author to whom correspondence should be addressed.
Received: 16 June 2011 / Revised: 13 July 2011 / Accepted: 18 July 2011 / Published: 19 July 2011
(This article belongs to the Section Natural Products)
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Abstract

A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), β-sitosterol (20), oxyresveratrol 2-O-β-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-β-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae). Their structures were determined by spectroscopic methods. The prenyl-flavonoids 1114, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes. The arylbenzofurans 110 and prenyl-flavonoids 1116 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.
Keywords: Morus alba var. multicaulis Perro; arylbenzofuran; prenyl-flavonoid; adipocyte; macrophage Morus alba var. multicaulis Perro; arylbenzofuran; prenyl-flavonoid; adipocyte; macrophage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, Z.-G.; Matsuzaki, K.; Takamatsu, S.; Kitanaka, S. Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells. Molecules 2011, 16, 6010-6022.

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