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A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9, rue Steichen L-2540, Luxembourg
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Received: 11 May 2011; in revised form: 31 May 2011 / Accepted: 31 May 2011 / Published: 30 June 2011
Abstract: Although considerable progress in oncology therapeutics has been achieved in the last century, cancer remains one of major death causes in the World and for this reason, the development of novel cancer drugs remains a pressing need. Natural marine compounds represent an interesting source of novel leads with potent chemotherapeutic or chemo-preventive activities. In the last decades, structure-activity-relationship studies have led to the development of naturally-derived or semi-synthetic analogues with improved bioactivity, a simplified synthetic target or less toxicity. We aim here to review a selection of natural compounds with reported anticancer activity isolated of marine sources and their associated analogues published in 2010.
Keywords: marine anticancer compounds; natural analogues; synthetic derivatives; cancer
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Schumacher, M.; Kelkel, M.; Dicato, M.; Diederich, M. A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010. Molecules 2011, 16, 5629-5646.
Schumacher M, Kelkel M, Dicato M, Diederich M. A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010. Molecules. 2011; 16(7):5629-5646.
Schumacher, Marc; Kelkel, Mareike; Dicato, Mario; Diederich, Marc. 2011. "A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010." Molecules 16, no. 7: 5629-5646.