Molecules 2011, 16(7), 5333-5348; doi:10.3390/molecules16075333
Review

Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo

1email, 2email and 3,* email
Received: 31 May 2011; in revised form: 21 June 2011 / Accepted: 21 June 2011 / Published: 24 June 2011
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl e-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
Keywords: levuglandin; polyunsaturated fatty acids; oxidative injury
PDF Full-text Download PDF Full-Text [189 KB, uploaded 18 June 2014 19:38 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zhang, M.; Li, W.; Li, T. Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo. Molecules 2011, 16, 5333-5348.

AMA Style

Zhang M, Li W, Li T. Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo. Molecules. 2011; 16(7):5333-5348.

Chicago/Turabian Style

Zhang, Ming; Li, Wei; Li, Tao. 2011. "Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo." Molecules 16, no. 7: 5333-5348.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert