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Molecules 2011, 16(7), 5333-5348; doi:10.3390/molecules16075333

Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo

1
Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2
Office of the Texas State Chemist, Texas A&M University, College Station, TX 77845, USA
3
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
*
Author to whom correspondence should be addressed.
Received: 31 May 2011 / Revised: 21 June 2011 / Accepted: 21 June 2011 / Published: 24 June 2011
(This article belongs to the Section Medicinal Chemistry)
Download PDF [189 KB, uploaded 18 June 2014]

Abstract

Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl e-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
Keywords: levuglandin; polyunsaturated fatty acids; oxidative injury levuglandin; polyunsaturated fatty acids; oxidative injury
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, M.; Li, W.; Li, T. Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo. Molecules 2011, 16, 5333-5348.

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