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Molecules 2011, 16(7), 5333-5348; doi:10.3390/molecules16075333
Review

Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo

1
,
2
 and
3,*
Received: 31 May 2011 / Revised: 21 June 2011 / Accepted: 21 June 2011 / Published: 24 June 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl e-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
Keywords: levuglandin; polyunsaturated fatty acids; oxidative injury levuglandin; polyunsaturated fatty acids; oxidative injury
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, M.; Li, W.; Li, T. Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo. Molecules 2011, 16, 5333-5348.

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