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Molecules 2011, 16(6), 5008-5019; doi:10.3390/molecules16065008
Article

Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate

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Received: 1 June 2011; in revised form: 10 June 2011 / Accepted: 15 June 2011 / Published: 17 June 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
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Abstract: Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral b-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic b-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.
Keywords: Evans-Tishchenko reduction; lithium binaphtholate; b-hydroxyketone; 1,3-diol; enantioselectivity Evans-Tishchenko reduction; lithium binaphtholate; b-hydroxyketone; 1,3-diol; enantioselectivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ichibakase, T.; Nakatsu, M.; Nakajima, M. Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate. Molecules 2011, 16, 5008-5019.

AMA Style

Ichibakase T, Nakatsu M, Nakajima M. Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate. Molecules. 2011; 16(6):5008-5019.

Chicago/Turabian Style

Ichibakase, Tomonori; Nakatsu, Masato; Nakajima, Makoto. 2011. "Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate." Molecules 16, no. 6: 5008-5019.



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