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Molecules 2011, 16(6), 5020-5034; doi:10.3390/molecules16065020
Article

Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters

* , , ,  and
Received: 31 May 2011; in revised form: 13 June 2011 / Accepted: 15 June 2011 / Published: 17 June 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
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Abstract: A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.
Keywords: asymmetric catalyst; bidentate phosphoramidite ligand; ruthenium catalyzed arylation asymmetric catalyst; bidentate phosphoramidite ligand; ruthenium catalyzed arylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yamamoto, Y.; Shirai, T.; Watanabe, M.; Kurihara, K.; Miyaura, N. Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters. Molecules 2011, 16, 5020-5034.

AMA Style

Yamamoto Y, Shirai T, Watanabe M, Kurihara K, Miyaura N. Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters. Molecules. 2011; 16(6):5020-5034.

Chicago/Turabian Style

Yamamoto, Yasunori; Shirai, Tomohiko; Watanabe, Momoko; Kurihara, Kazunori; Miyaura, Norio. 2011. "Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters." Molecules 16, no. 6: 5020-5034.


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