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Molecules 2011, 16(4), 3420-3432; doi:10.3390/molecules16043420

Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents

School of Chemistry, Research Centre in Catalysis and Intensified Processing, Bedson Building, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
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Received: 6 April 2011 / Revised: 19 April 2011 / Accepted: 20 April 2011 / Published: 21 April 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
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Abstract

Propylene carbonate is shown to be an environmentally friendly and sustainable replacement for dichloromethane and acetonitrile in proline-catalysed a-hydrazinations of aldehydes and ketones. Enantioselectivities comparable to those obtained in conventional solvents or ionic liquids can be obtained, even when using a lower catalyst loading.
Keywords: proline; amination; cyclic-carbonate proline; amination; cyclic-carbonate
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Beattie, C.; North, M.; Villuendas, P. Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents. Molecules 2011, 16, 3420-3432.

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