Next Article in Journal
Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
Next Article in Special Issue
Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate
Previous Article in Journal
Synthesis and Anticancer Activity of Some Novel Tetralin-6-yl-pyrazoline, 2-Thioxopyrimidine, 2-Oxopyridine, 2-Thioxo-pyridine and 2-Iminopyridine Derivatives
Previous Article in Special Issue
Catalytic Enantioselective Aryl Transfer to Aldehydes Using Chiral 2,2’-Bispyrrolidine-Based Salan Ligands
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(4), 3420-3432; https://doi.org/10.3390/molecules16043420

Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents

School of Chemistry, Research Centre in Catalysis and Intensified Processing, Bedson Building, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
*
Author to whom correspondence should be addressed.
Received: 6 April 2011 / Revised: 19 April 2011 / Accepted: 20 April 2011 / Published: 21 April 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
Download PDF [214 KB, uploaded 18 June 2014]   |  

Abstract

Propylene carbonate is shown to be an environmentally friendly and sustainable replacement for dichloromethane and acetonitrile in proline-catalysed a-hydrazinations of aldehydes and ketones. Enantioselectivities comparable to those obtained in conventional solvents or ionic liquids can be obtained, even when using a lower catalyst loading.
Keywords: proline; amination; cyclic-carbonate proline; amination; cyclic-carbonate
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Beattie, C.; North, M.; Villuendas, P. Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents. Molecules 2011, 16, 3420-3432.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top