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Molecules 2011, 16(6), 4897-4911; doi:10.3390/molecules16064897

Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

1
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, Shanxi, China
2
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
*
Author to whom correspondence should be addressed.
Received: 27 April 2011 / Revised: 1 June 2011 / Accepted: 7 June 2011 / Published: 14 June 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.
Keywords: halophenols; furan-2-yl(phenyl)methanone; protein tyrosine kinases inhibitor; structure-activity relationships (SAR) halophenols; furan-2-yl(phenyl)methanone; protein tyrosine kinases inhibitor; structure-activity relationships (SAR)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zheng, F.L.; Ban, S.R.; Feng, X.E.; Zhao, C.X.; Lin, W.; Li, Q.S. Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives. Molecules 2011, 16, 4897-4911.

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