Molecules 2011, 16(6), 4850-4860; doi:10.3390/molecules16064850
Article

Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B

1 College of Pharmacy, the Institute of Health Sciences, Gyeongsang National University, Jinju daero, Jinju, Gyeongnam, 660-751, Korea 2 College of Pharmacy, Seoul National University, Gwanak-ro 599, Gwanak-gu, Seoul 151-742, Korea
* Author to whom correspondence should be addressed.
Received: 27 April 2011; in revised form: 26 May 2011 / Accepted: 7 June 2011 / Published: 10 June 2011
(This article belongs to the Special Issue Polyketide)
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Abstract: Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile procedure for the construction of the macrolactone skeleton of macrosphelide B in terms of facial selectivity. Our preliminary and unprecedented stereoselective procedure is anticipated to be usefully applied through further studies for the synthesis of the macrosphelide family.
Keywords: intramolecular nitrile oxide cycloaddition; macrosphelide; polyketide; total synthesis; phase transfer catalyst

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MDPI and ACS Style

Paek, S.-M.; Suh, Y.-G. Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B. Molecules 2011, 16, 4850-4860.

AMA Style

Paek S-M, Suh Y-G. Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B. Molecules. 2011; 16(6):4850-4860.

Chicago/Turabian Style

Paek, Seung-Mann; Suh, Young-Ger. 2011. "Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B." Molecules 16, no. 6: 4850-4860.

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