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Recent Advances in the Studies on Luotonins
AbstractLuotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNA-cleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered.
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Liang, J.L.; Cha, H.C.; Jahng, Y. Recent Advances in the Studies on Luotonins. Molecules 2011, 16, 4861-4883.View more citation formats
Liang JL, Cha HC, Jahng Y. Recent Advances in the Studies on Luotonins. Molecules. 2011; 16(6):4861-4883.Chicago/Turabian Style
Liang, Jing Lu; Cha, Hyo Chang; Jahng, Yurngdong. 2011. "Recent Advances in the Studies on Luotonins." Molecules 16, no. 6: 4861-4883.