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Molecules 2011, 16(6), 4861-4883; doi:10.3390/molecules16064861
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Recent Advances in the Studies on Luotonins

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Received: 12 April 2011; in revised form: 8 June 2011 / Accepted: 10 June 2011 / Published: 14 June 2011
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Abstract: Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNA-cleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered.
Keywords: luotonin A; luotonin B; luotonin C; luotonin D; luotonin E; luotonin F; topoisomerase I; topoisomerase II luotonin A; luotonin B; luotonin C; luotonin D; luotonin E; luotonin F; topoisomerase I; topoisomerase II
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liang, J.L.; Cha, H.C.; Jahng, Y. Recent Advances in the Studies on Luotonins. Molecules 2011, 16, 4861-4883.

AMA Style

Liang JL, Cha HC, Jahng Y. Recent Advances in the Studies on Luotonins. Molecules. 2011; 16(6):4861-4883.

Chicago/Turabian Style

Liang, Jing Lu; Cha, Hyo Chang; Jahng, Yurngdong. 2011. "Recent Advances in the Studies on Luotonins." Molecules 16, no. 6: 4861-4883.


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