Special Issue "Polyketide"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 April 2011)
Dr. James T. Kealey
Amyris Biotechnologies, 5885 Hollis Street, Suite 100, Emeryville, CA 94608, USA
Related Special Issues in other JournalsPolyketide in Pharmaceuticals
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- metabolic engineering
- synthetic biology
- natural products
- heterologous production
- renewable fuels and chemicals
Article: Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B
Molecules 2011, 16(6), 4850-4860; doi:10.3390/molecules16064850
Received: 27 April 2011; in revised form: 26 May 2011 / Accepted: 7 June 2011 / Published: 10 June 2011| Download PDF Full-text (366 KB)
Molecules 2011, 16(7), 6092-6115; doi:10.3390/molecules16076092
Received: 8 June 2011; in revised form: 6 July 2011 / Accepted: 18 July 2011 / Published: 20 July 2011| Download PDF Full-text (1154 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Lichens as Natural Chemical Cell Factories and Potential Sources of Novel Pharmaceuticals: Investigating Polyketide Production in Lichen-Forming Fungi by Using in vitro Cultured Mycobionts
Author: Elfie Stocker-Wörgötter
Affiliation: Department of Organismic Biology, University of Salzburg, Hellbrunner Str. 34, A-5020 Salzburg, Austria; E-Mail: Elfriede.Stocker@sbg.ac.at
Abstract: Lichens are unique life forms that depend upon the symbiotic relationship of an ascomycetous fungus (in most cases) living together with green algal and/or cyanobacterial photobionts. Nutrionally, lichens are highly specialized fungi that derive carbon and in some cases also nitrogen from the photo-and cyanobionts hosted in a thallus. Lichen fungi produce an extensive array of secondary metabolites which can comprise high concentrations of up to 20% thallus dry weight. Most of the accumulated and crystallised secondary compounds are chemically classified as aromatic and aliphatic polyketides (large ring compounds – macrolides). Future perpectives to use cultured mycobionts (culture optimization) instead of natural thalli for the production of particular polyketides are highlighted. Cultured mycobionts have turned out to be excellent model systems for studying Pks pathways in vitro.
Last update: 13 October 2010