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Molecules 2011, 16(3), 2519-2526; doi:10.3390/molecules16032519

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

*  and *
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 15 February 2011 / Revised: 2 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011
(This article belongs to the Section Medicinal Chemistry)
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Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
Keywords: synthesis; acenaphthene derivatives; antitumour activity synthesis; acenaphthene derivatives; antitumour activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xie, Y.-M.; Deng, Y.; Dai, X.-Y.; Liu, J.; Ouyang, L.; Wei, Y.-Q.; Zhao, Y.-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules 2011, 16, 2519-2526.

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