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Molecules 2011, 16(3), 2519-2526; doi:10.3390/molecules16032519

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

*  and *
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 15 February 2011 / Revised: 2 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011
(This article belongs to the Section Medicinal Chemistry)
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Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
Keywords: synthesis; acenaphthene derivatives; antitumour activity synthesis; acenaphthene derivatives; antitumour activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xie, Y.-M.; Deng, Y.; Dai, X.-Y.; Liu, J.; Ouyang, L.; Wei, Y.-Q.; Zhao, Y.-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules 2011, 16, 2519-2526.

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