Molecules 2011, 16(3), 2519-2526; doi:10.3390/molecules16032519
Article

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 15 February 2011; in revised form: 2 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
Keywords: synthesis; acenaphthene derivatives; antitumour activity

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MDPI and ACS Style

Xie, Y.-M.; Deng, Y.; Dai, X.-Y.; Liu, J.; Ouyang, L.; Wei, Y.-Q.; Zhao, Y.-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules 2011, 16, 2519-2526.

AMA Style

Xie Y-M, Deng Y, Dai X-Y, Liu J, Ouyang L, Wei Y-Q, Zhao Y-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules. 2011; 16(3):2519-2526.

Chicago/Turabian Style

Xie, Yong-Mei; Deng, Yi; Dai, Xiao-Yun; Liu, Jie; Ouyang, Liang; Wei, Yu-Quan; Zhao, Ying-Lan. 2011. "Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents." Molecules 16, no. 3: 2519-2526.

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