Molecules 2011, 16(3), 2519-2526; doi:10.3390/molecules16032519
Article

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

Yong-Mei Xie † email, Yi Deng † email, Xiao-Yun Daiemail, Jie Liuemail, Liang Ouyangemail, Yu-Quan Wei* email and Ying-Lan Zhao* email
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 15 February 2011; in revised form: 2 March 2011 / Accepted: 10 March 2011 / Published: 17 March 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by 1H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
Keywords: synthesis; acenaphthene derivatives; antitumour activity

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Cite This Article

MDPI and ACS Style

Xie, Y.-M.; Deng, Y.; Dai, X.-Y.; Liu, J.; Ouyang, L.; Wei, Y.-Q.; Zhao, Y.-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules 2011, 16, 2519-2526.

AMA Style

Xie Y-M, Deng Y, Dai X-Y, Liu J, Ouyang L, Wei Y-Q, Zhao Y-L. Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents. Molecules. 2011; 16(3):2519-2526.

Chicago/Turabian Style

Xie, Yong-Mei; Deng, Yi; Dai, Xiao-Yun; Liu, Jie; Ouyang, Liang; Wei, Yu-Quan; Zhao, Ying-Lan. 2011. "Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents." Molecules 16, no. 3: 2519-2526.

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