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Molecules 2011, 16(3), 2527-2541; doi:10.3390/molecules16032527

Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.

1 Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Via Ponte Don Melillo,1 84084 Fisciano (SA), Italy 2 Pontificia Universidad Catolica del Perù, Apartado, 1761, Lima, Peru 3 Dipartimento di Chimica, Università degli Studi della Basilicata, Viale dell’Ateneo Lucano,10 85100 Potenza, Italy 4 Dipartimento di Patologia e Sanità Animale, Sez. Tossicologia, Università di Napoli Federico II, Via Del Pino,1 80137, Napoli, Italy
* Author to whom correspondence should be addressed.
Received: 24 January 2011 / Revised: 11 March 2011 / Accepted: 15 March 2011 / Published: 17 March 2011
(This article belongs to the Section Natural Products)
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Four new bibenzyl derivatives were isolated, together with other known bibenzyls, by bioassay-guided fractionation of a CHCl3-MeOH extract of Notholaena nivea Desv. (Pteridaceae) aerial parts. The structures were elucidated by NMR, ESIMS and other spectral analyses. Their antioxidative effects towards superoxide, lipidic peroxidation and the 2,2'-azino-bis-3-ethilbenzothiazoline-6-sulfonic acid (ABTS) radical were assayed. Results showed that the compound 3,12-dihydroxy-5-methoxybibenzyl (6) is the most active compound in the ABTS free-radical scavenging test, while in the coupled oxidation of β-carotene and linoleic acid assay the compound 5,12-dihydroxy-3-methoxydibenzyl-6-carboxylic acid (1) exerted the highest activity after 1h. A superoxide anion enzymatic test was also carried out and the results were confirmed by an inhibition of xanthine oxidase activity assay. The putative protective role played by compounds 1 and 6 on the injurious effects of reactive oxygen metabolites on the intestinal epithelium, using a Caco-2 human cell line, was investigated. H2O2-induced alterations were prevented by preincubating the cells with compounds 1 and 6.
Keywords: Notholaena nivea; bibenzyl derivatives; NMR; antioxidants activity Notholaena nivea; bibenzyl derivatives; NMR; antioxidants activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cioffi, G.; Montoro, P.; Ugaz, O.L.D.; Vassallo, A.; Severino, L.; Pizza, C.; Tommasi, N.D. Antioxidant Bibenzyl Derivatives from Notholaena nivea Desv.. Molecules 2011, 16, 2527-2541.

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