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Molecules 2011, 16(3), 2075-2083; doi:10.3390/molecules16032075
Article

In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose

1
, 1
, 2
 and 3,4,*
Received: 10 January 2011; in revised form: 7 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Section Medicinal Chemistry)
Download PDF [250 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: The inhibitory activity on pancreatic α-amylase by cyanidin-3-rutinoside was examined in vitro. The IC50 value of cyanidin-3-rutinoside against pancreatic α-amylase was 24.4 ± 0.1 μM. The kinetic analysis revealed that pancreatic α-amylase was inhibited by cyanidin-3-rutinoside in a non-competitive manner. The additive inhibition of a combination of cyanidin-3-rutinoside with acarbose against pancreatic α-amylase was also found. These results provide the first evidence for the effect of cyanidin-3-rutinoside in a retarded absorption of carbohydrates by inhibition of pancreatic α-amylase which may be useful as a potential inhibitor for prevention and treatment of diabetes mellitus.
Keywords: cyanidin-3-rutinoside; pancreatic α-amylase; acarbose; additive inhibition cyanidin-3-rutinoside; pancreatic α-amylase; acarbose; additive inhibition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Akkarachiyasit, S.; Yibchok-Anun, S.; Wacharasindhu, S.; Adisakwattana, S. In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose. Molecules 2011, 16, 2075-2083.

AMA Style

Akkarachiyasit S, Yibchok-Anun S, Wacharasindhu S, Adisakwattana S. In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose. Molecules. 2011; 16(3):2075-2083.

Chicago/Turabian Style

Akkarachiyasit, Sarinya; Yibchok-Anun, Sirintorn; Wacharasindhu, Sumrit; Adisakwattana, Sirichai. 2011. "In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose." Molecules 16, no. 3: 2075-2083.


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